Luxury Hotels & Resorts in Antofagasta

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Best Antofagasta Luxury Hotels

Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.

Frequently asked questions

Are you searching for the perfect hotel for your luxury holiday in Antofagasta?
Antofagasta has some interesting things to see and do including Plaza Colon and Antofagasta Fish Market, so you might want to take in the local sights during your visit.
What's the best high-end hotel in Antofagasta?
Enjoy Antofagasta is a luxury hotel with 2 restaurants and spa services, and it’s a popular choice for Expedia travellers looking for an elegant place to stay. Another upscale option for your stay is Hotel Florencia Suites & Apart.
How many luxury hotels can I expect to find in Antofagasta?
Lie in the lap of luxury during your getaway to Antofagasta in one of Expedia’s 6 luxury hotels.
When can I expect good weather in Antofagasta?
Planning for the weather is a good way to make your trip to Antofagasta relaxing and enjoyable, especially when you’re splurging. The hottest months are usually February and January, with an average temperature of 20°C, while the coldest months are July and August, with an average of 15°C. Between January and March, the daytime average is 24°C and the night-time average is 18°C. Between April and June, temperatures average 21°C during the day and 13°C at night. Between July and September, the temperature averages 18°C during the day and 12°C at night. Between October and December, the average temperature is 22°C during the day and 13°C at night.
What's there to see and do in Antofagasta?
Enjoy all that Antofagasta has to offer when you visit Plaza Colon, Antofagasta Fish Market and Antofagasta Regional Stadium. If you have spare time during your trip, you might want to make a stop at Hand of the Desert and Cerro Paranal Observatory.
How can I get around Antofagasta?
It’s easier to get around town in style when you know your options. If you’d like to explore more of the area, hop on a train from Antofagasta Station, O’Higgins Station or La Negra Station.