Eastern Panama Holidays from AU$648

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

    • payments icon

    Better together

    Save up to AU$703 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

Your Eastern Panama Holiday

Leave all the planning to us with an Eastern Panama holiday package. With everything organised before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama holiday into reality.

The Latest Eastern Panama Holiday Deals

Price found within the past 48 hours. Click for updated prices.
Hotel Casa Panamá

Hotel Casa Panamá

4 out of 5
Casco Viejo
per person
22 Sept - 26 Sept
found 1 day ago
Return flight included
Cali (CLO) to Panama City (PTY)
7.4/10 Good! (553 reviews)
The hotel was average. The shower was never warm. It took some getting used to taking cold showers. But, otherwise it was in a very convenient location where you can walk to all attractions in Casco. There is a strong police presence so I always felt safe. Prices are expensive in this area.

Reviewed on 3 Aug. 2025

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
per person
22 Sept - 26 Sept
found 1 day ago
Return flight included
Cali (CLO) to Panama City (PTY)
9/10 Wonderful! (4,141 reviews)
Liked it overall. Good breakfast the only thing its that you get bored easily, also the pool was only functional one day out of my stay.

Reviewed on 9 Aug. 2025

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
per person
22 Sept - 26 Sept
found 1 day ago
Return flight included
Cali (CLO) to Panama City (PTY)
8.4/10 Very Good! (997 reviews)
Extremely Disappointed — Not Worth the Stay From the moment I stepped into the hallway, I was met with a strong, mouldy odour, which carried over into the room. The carpet was visibly dirty, and the air throughout felt stale and unclean. The room was not cleaned daily, and fresh towels were not provided unless repeatedly requested. I had to call several times just to receive basic essentials like tissue and bottled water, which should have been standard. To make matters worse, the breakfast options were extremely limited and remained the same every day. There was no variety or effort to offer guests a better experience during their stay. Overall, this was a very poor showing for a hotel. The lack of cleanliness, poor service, and subpar amenities made the stay deeply disappointing. I would not recommend this property unless significant improvements are made across the board.

Reviewed on 8 Aug. 2025

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
San Francisco
per person
22 Sept - 26 Sept
found 1 day ago
Return flight included
Cali (CLO) to Panama City (PTY)
8.8/10 Excellent! (1,004 reviews)
The property very nice and well taking care of.

Reviewed on 7 Aug. 2025

MARINN PLACE Financial District

MARINN PLACE Financial District

3.5 out of 5
Bella Vista
per person
22 Sept - 26 Sept
found 1 day ago
Return flight included
Cali (CLO) to Panama City (PTY)
9.2/10 Wonderful! (290 reviews)
Friendly staff. Helped with airport transportation for an overnight layover

Reviewed on 24 Jul. 2025

Eastern Panama Holiday

Eastern Panama Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)
Top Sights
Portobelo National Park, Isla Mamey and Cayos Holandeses

Our pick of the best Eastern Panama Hotel Deals

Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande, Isla Grande, Colon
10/10 Exceptional! (2 reviews)
"The Ordovician Hotel is a hidden gem on the peaceful west side of Isla Grande. From the moment we booked, the service was personal and seamless—thank you, Yohan! We were welcomed by name, greeted with a delicious tropical drink, and felt like cherished guests from start to finish. We stayed in the ..."

Reviewed on 25 Jul. 2025

Get rates
Ordovician Beach Resort
Ciel y Miel

Ciel y Miel

3 out of 5
Caillle Principale, Cacique, Provincia de Colón
10/10 Exceptional! (9 reviews)
"All was good"

Reviewed on 14 Jul. 2025

Get rates
Ciel y Miel
Private Over the Water Cabin on San Blas Island

Private Over the Water Cabin on San Blas Island

2 out of 5
9.542876, -78.899058, Narganá, San Blas
"Communication was good and highly organized. We felt safe and didn’t need to lock up our bags or valuables at all times. Weather was rough (not their fault) so the stay was a challenge with super high winds and rain. The island was covered in trash nearly all the way around. Our cabin doors were ..."

Reviewed on 16 Feb. 2022

Get rates
Private Over the Water Cabin on San Blas Island
See all 168 properties in Eastern Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
All Inclusive Holidays
Cheap Holidays
Cheap Holidays
Cheap Holidays
beach holidays
Beach Holidays
Beach Holidays

What to do in Eastern Panama

Vibrant Gong and Yoga Baths

Vibrant Gong and Yoga Baths

AU$69
per adult
Vibrant Gong and Yoga Baths
See all activities in Eastern Panama

Frequently asked questions

How much does an Eastern Panama holiday package cost?
The most affordable Eastern Panama holiday package is AU$648, so your dream getaway can become a reality — without breaking the bank. Bundle flights, hotels and car rentals to tailor make a package that matches your travelling style.
How do I get a cheap travel package to Eastern Panama?
Lock in flights that suit your schedule, add a hotel to your booking and watch the savings pile up with an Eastern Panama holiday package. It's as simple as that! From flights and hotels to rental cars and activities, Expedia is where your cheap getaway begins. And with over 550 air carriers and 1 000 000 hotels around the world to choose from, you won't be short of choice.
What are the top hotels in Eastern Panama?
For hotels in San Blas Islands with friendly service and cosy beds, look up Private Over The Water Cabin On San Blas Island and San Blas Private Over - The - Water Cabin. If you plan to explore Narganá as well, you can look forward to a great night's sleep at Paradise Over The Water Cabins In San Blas or San Blas Private Over - The - Water Cabin.
How far in advance should I book my Eastern Panama holiday?
Smart travellers often reserve their seats as early as possible. You can generally look up international fares on Expedia up to 12 months before your intended flight. If you're booking last minute, don't despair. Low prices sometimes occur just weeks prior to departure.
What does an Expedia Eastern Panama travel package include?
Flights, rental cars and hotels, or any combination of the three — it's your choice. Whether you're visiting Eastern Panama with the kids or travelling by yourself, there's a package to fit every style and budget. Once you've made your booking, why not add on a couple of tours or activities?
What should I know before booking an Eastern Panama travel package?
Booking all the parts of your getaway together is an excellent way to save. Combine your car rentals, flights and hotels into a neat little package. But it's not just hotels. Expedia features all types of properties, including holiday homes like mountain cabins and city apartments. Your choices are almost endless!
Can I choose my airline with an Eastern Panama Expedia holiday package?
Yes — that's the beauty of an Expedia holiday package. You're in charge! We have access to more than 550 airline partners across the globe, so you have loads of choice when planning your Eastern Panama getaway.
If I'm not able to travel, can I cancel my Eastern Panama holiday package?
You can. We realise life doesn't always go to plan, so we're happy to help if you have to make changes to your Eastern Panama holiday package. You may be able to cancel or change your itinerary for free if you've booked within 24 hours. Your hotel, airline or car rental company may charge you a fee if your booking was made more than 24 hours ago. Look up our Customer Service Portal for more information. Also, check your itinerary for the finer details on change fees.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.