Search Isla Santa María hotels

  • Plan, book, stay with confidence
  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Check Isla Santa María hotel prices

Tomorrow night
Next weekend

Filter by

Guest rating
Guest rating
Property class

Top hotels and accommodation in Isla Santa María

Floreana Island

2.0 star property
Floreana Island
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Isla Santa María
Save an average of 15% on thousands of hotels when you're signed in
Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.

Frequently asked questions

Where is the best place for a stay in Isla Santa María?

Located 38.7 mi (62.3 km) from the heart of Isla Santa María, Blu Galapagos Sustainable Waterfront Lodge is a top choice for your stay, based on our traveller data. Other good choices for your stay in the area are Hostal North Seymour and Hotel Fiesta. See all available top hotels, or vacation rentals in Isla Santa María.

What are some of the best holiday rentals that Isla Santa María has to offer?

Villa Galapagos: This holiday home rental outside of Isla Santa María is located near the beach, and offers a private garden, air conditioning and daily housekeeping to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop and a microwave. See all vacation rentals in Isla Santa María.

If I need to cancel my hotel reservation in Isla Santa María, will I receive a refund?

Yes, the majority of hotel reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If your reservation is non-refundable, it may still be possible to cancel it and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Isla Santa María.

What is staying in Isla Santa María like?

Travellers to Isla Santa María will find plenty to explore and enjoy. There are 185 hotels and other accommodation options in the larger region. Find out more about Isla Santa María.

What is there to see in Isla Santa María?

Favourite places to visit include Galápagos National Park, Post Office Bay and Punta Suarez. Take a look at what more there is to see and do in Expedia's Isla Santa María guide.

What's the seasonal weather in Isla Santa María?

The hottest months are usually March and February, with an average temperature of 26°C, while the coldest months are September and October, with an average of 22°C. Average annual precipitation for Isla Santa María is 319 mm.