Luxury Hotels & Resorts in Main Street Hyannis from AU$146

  • Plan, book, stay with confidence
    • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    today icon
    Change your mind
    Book hotels with free cancellation

Best Main Street Hyannis Luxury Hotels

Hyannis Plaza Hotel
Lobby

Hyannis Plaza Hotel

2.5 star property
6.8 out of 10, (676)
"I paid online for the weekend and then an additional amount that I didn’t know about when checking in and I was told that it would be back in my account Monday morning and have not received it yet. "
The price is AU$152
includes taxes & fees
22 Dec - 23 Dec
Hyannis Plaza Hotel
Americas Best Value Inn & Suites Hyannis Cape Cod
Indoor pool, seasonal outdoor pool, pool loungers

Americas Best Value Inn & Suites Hyannis Cape Cod

2.0 star property
7.4 out of 10, Good, (1027)
"Good"
Americas Best Value Inn & Suites Hyannis Cape Cod
Cape Cod Inn
Marina

Cape Cod Inn

2.0 star property
8.8 out of 10, Excellent, (422)
"The Cape Cod Inn is a decent motel. The rooms are clean and spacious and quiet. We found it very convenient to park outside our door. It’s a very short walk to restaurants and shops and a ten minute walk to the ferry to either Nantucket or Martha’s Vineyard. Good value for the money, would definitely stay again. "
Cape Cod Inn
Comfort Inn Hyannis - Cape Cod
Desk, blackout curtains, iron/ironing board, free WiFi

Comfort Inn Hyannis - Cape Cod

2.5 star property
7.6 out of 10, Good, (1008)
"Great "
The price is AU$146
includes taxes & fees
23 Dec - 24 Dec
Comfort Inn Hyannis - Cape Cod
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Main Street Hyannis
Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.
Unlock Black Friday deals

Frequently asked questions

Are you looking for a luxury hotel for your stay in Main Street Hyannis?
During your visit, you might want to enjoy the beaches and shopping which Main Street Hyannis is known for.
What's the best high-end place to stay in Main Street Hyannis?
Hyannis Plaza Hotel is a luxury hotel with a seasonal outdoor pool and a bar, and it’s a popular choice for Expedia travellers looking for an elegant place to stay.
How many luxury hotels will I be able to find in Main Street Hyannis?
Lie in the lap of luxury during your getaway to Main Street Hyannis in one of Expedia’s 6 luxury hotels.
When can I expect good weather in Main Street Hyannis?
Planning for the weather is an important factor for making your trip to Main Street Hyannis a success, especially when you’re splurging. The hottest months are usually August and July, with an average temperature of 20°C, while the coldest months are February and January, with an average of 3°C. Average annual precipitation for Main Street Hyannis is 1328 mm.
What's there to see and do in Main Street Hyannis?
Experience Main Street Hyannis with a stop at John F. Kennedy Hyannis Museum, Cape Cod Baseball Hall of Fame and Wackenhammer’s Clockwork Arcade. If you have extra time while you’re in the area, you might want to stop by Cape Cod Maritime Museum and Hyannis Harbor.