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Top hotels and accommodation in Melrose

Waterfront Nature Oasis Right off the Interstate
9.8 out of 10, Exceptional, (8)
"Nice quiet get away. Will visit again!"
Waterfront Nature Oasis Right off the Interstate
Little Riverbank cottage is a unit on the river banks of the Cane River.
2.0 star property
10.0 out of 10, Exceptional, (1)
"The cabin was very clean and the host was the sweetest to work with."
Little Riverbank cottage is a unit on the river banks of the Cane River.
Cozy, comfortable home overlooking Cane River -15 min from downtown Natchitoches
10.0 out of 10, Exceptional, (21)
"Had a great trip to Natchitoches for our girls weekend. We debated staying in town versus on the river and we’re glad we stayed on the river. The place was beautiful, comfortable and perfect for our trip. We enjoyed the outside area each night, even though it was too hot to use the fire pit. Next time we stay here we’ll make sure it’s cool enough for that! :)"
Cozy, comfortable home overlooking Cane River -15 min from downtown Natchitoches
Charming water front cottage on Cane River with stunning sunroom & private decks
9.8 out of 10, Exceptional, (7)
"House was as advertised. Fishing was great. We caught over 70 bream. Only one garbage bag was supplied. The dishwasher was broken. The TV in the main bedroom was not working right. These issues would not be particularly important except for the fact that the rate was $275 a night. Otherwise, the location, views and fishing were very nice."
Charming water front cottage on Cane River with stunning sunroom & private decks
Relax, Enjoy, Explore, On Cane!
9.8 out of 10, Exceptional, (11)
"First, we never intended to stay at this property. The original VRBO we had booked canceled last minute, because of flooding in that area. When we arrived, we were very pleased with the cleanliness, and beyond the normal comforts were available, should we need anything. We travel with all of our own blankets, and even pack laundry soap and dishwasher detergents, but had we needed for anything, the host had seen to every detail. A few nice games were available for the kids, throw blankets were...
Relax, Enjoy, Explore, On Cane!
Rustic cottage on Cane River. Perfect place to relax, fish, and enjoy the water
9.4 out of 10, Exceptional, (26)
"The location was fantastic and the river was beautiful! The house was very quiet and comfortable and we greatly enjoyed the outdoor space. My only complaint was it could have been clearer, I understand it’s Louisiana and we were beside the water so bugs are a given."
Rustic cottage on Cane River. Perfect place to relax, fish, and enjoy the water
Water front Home on Cane River
9.8 out of 10, Exceptional, (91)
"Wonderful property well provisioned beautiful dock on the lake.Fish all day, every day caught fish all day every day. Would absolutely. stay here ag"
Water front Home on Cane River
Modern Natchitoches Retreat on Cane River!
3.0 star property
Modern Natchitoches Retreat on Cane River!
Nantachie Water View Lake House
9.8 out of 10, Exceptional, (11)
"Pictures hardly do this property justice. Clean and great location, hosts very welcoming. Close proximity to grandchildren and we will surely return. Thank you!"
Nantachie Water View Lake House
Home Away from Home
10.0 out of 10, Exceptional, (4)
"Good quiet neighborhood by the lake"
Home Away from Home
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Beautiful view of the beach with palm trees

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Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.

Frequently asked questions

What's the best place for a stay in Melrose?

Chateau St. Denis a Historic Downtown Hotel, located 13.4 mi (21.5 km) from the heart of Melrose, is a top choice for your stay, based on our traveller data. Other good options for your stay in the area are Comfort Suites Natchitoches and Fairfield Inn & Suites Natchitoches. See all available top hotels, or vacation rentals in Melrose.

What are some of the best holiday rentals that Melrose has to offer?

Newly remodeled 1930's cottage! Close to everything in the heart of Natchitoches: This holiday home rental outside of Melrose is located on a river, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 6 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You can relax into your holiday with a selection of games and 1 hot tub. See all vacation rentals in Melrose.

If I need to cancel my hotel reservation in Melrose, will I receive a refund?

Yes, most hotel bookings are refundable if you cancel before the hotel’s cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you have a non-refundable reservation, it may still be possible to cancel it and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Melrose.

What are some hotels with pools in Melrose?

Fairfield Inn & Suites Natchitoches: Offers a children's pool, a seasonal outdoor pool and free breakfast. Comfort Suites Natchitoches and Best Western Natchitoches Inn are a couple of other choices that offer an on-site pool. View all hotels with pools in Melrose.

What is staying in Melrose like?

Travellers to Melrose will find plenty to explore and enjoy. There are 70 hotels and other accommodation options in the surrounding area. Find out more about Melrose.

What should I see while I'm in Melrose?

Places to visit in the wider area include Cane River National Heritage Area, Historic District Shopping and Cane River Creole National Historical Park. You'll also find Prather Coliseum and Old Courthouse Museum in the area. Take a look at what more there is to see and do in Expedia's Melrose guide.

What's the weather like in Melrose?

The hottest months are usually August and July, with an average temperature of 27°C, while the coldest months are January and February, with an average of 11°C. Average annual precipitation for Melrose is 1431 mm.