Search O Brien hotels

Start date: Check-in selected.
To Date
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Top hotels and accommodation in O Brien

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 star property
9.4 out of 10, Exceptional, (1001)
"Clean rooms, helpful staff, great breakfast"
The price is AU$199
includes taxes & fees
5 Oct - 6 Oct
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Americas Best Value Inn Alachua

2.0 star property
4.8 out of 10, (581)
"Staff very helpful and property clean"
The price is AU$98
includes taxes & fees
13 Oct - 14 Oct
Americas Best Value Inn Alachua

Hampton Inn & Suites Alachua I-75

2.5 star property
9.4 out of 10, Exceptional, (459)
"It's a new clean and nice hotel "
The price is AU$198
includes taxes & fees
12 Oct - 13 Oct
Hampton Inn & Suites Alachua I-75

La Quinta Inn & Suite by Wyndham Lake City

2.5 star property
8.8 out of 10, Excellent, (1000)
"The breakfast was great and beds were comfortable "
The price is AU$161
includes taxes & fees
5 Oct - 6 Oct
La Quinta Inn & Suite by Wyndham Lake City

High Springs Country Inn

2.0 star property
8.6 out of 10, Excellent, (8)
"STAFF WAS GREAT. ROOM WAS CLEAN BUT COULD USE A LUTTLE RENAVATION "
The price is AU$123
includes taxes & fees
15 Oct - 16 Oct
High Springs Country Inn

Courtyard By Marriott Lake City

3.0 star property
9.6 out of 10, Exceptional, (144)
"Great hotel "
The price is AU$167
includes taxes & fees
12 Oct - 13 Oct
Courtyard By Marriott Lake City

Best Western Plus Lake City

2.5 star property
9.2 out of 10, Wonderful, (1031)
"We stayed one night and staff was friendly, room was clean and comfy beds. Will stay here again. "
The price is AU$151
includes taxes & fees
19 Oct - 20 Oct
Best Western Plus Lake City

Comfort Suites Lake City

2.5 star property
9.6 out of 10, Exceptional, (1001)
"Amazing place to stay"
The price is AU$158
includes taxes & fees
8 Oct - 9 Oct
Comfort Suites Lake City

Postcard Cabins Gilchrist Springs

2.0 star property
10.0 out of 10, Exceptional, (119)
"Beautiful cabin and stay "
The price is AU$256
includes taxes & fees
6 Oct - 7 Oct
Postcard Cabins Gilchrist Springs

Quality Inn Lake City

2.5 star property
7.8 out of 10, Good, (929)
"Very nice place, would definitely stay there again!"
The price is AU$129
includes taxes & fees
2 Nov - 3 Nov
Quality Inn Lake City

Tru by Hilton Lake City

2.5 star property
9.2 out of 10, Wonderful, (1001)
"Staff was friendly, hotel was clean and close to resturants in the area."
The price is AU$185
includes taxes & fees
12 Oct - 13 Oct
Tru by Hilton Lake City

Baymont by Wyndham Lake City

2.5 star property
5.0 out of 10, (1000)
"Room was clean. Bed was comfy. Folks up front were super nice. "
The price is AU$98
includes taxes & fees
12 Oct - 13 Oct
Baymont by Wyndham Lake City

Days Inn by Wyndham Lake City I-10

2.0 star property
6.8 out of 10, (1006)
"All was good. Staff was great."
The price is AU$95
includes taxes & fees
5 Oct - 6 Oct
Days Inn by Wyndham Lake City I-10

Quality Inn White Springs Suwanee

2.5 star property
7.2 out of 10, Good, (582)
"Clean, Location"
The price is AU$125
includes taxes & fees
5 Oct - 6 Oct
Quality Inn White Springs Suwanee

Americas Best Value Inn Lake City

2.0 star property
8.8 out of 10, Excellent, (1000)
"Friendly staff. Clean and comfortable rooms!"
The price is AU$115
includes taxes & fees
5 Oct - 6 Oct
Americas Best Value Inn Lake City

BlueGem Motel

2.0 star property
9.2 out of 10, Wonderful, (372)
"Great place to stay."
The price is AU$153
includes taxes & fees
7 Oct - 8 Oct
BlueGem Motel

Fairfield Inn & Suites Lake City

2.5 star property
9.0 out of 10, Wonderful, (131)
"Friendly staff"
The price is AU$151
includes taxes & fees
13 Oct - 14 Oct
Fairfield Inn & Suites Lake City

Days Inn by Wyndham Lake City I-75

2.0 star property
7.4 out of 10, Good, (1000)
"The staff was nice and check in was easy"
The price is AU$110
includes taxes & fees
5 Oct - 6 Oct
Days Inn by Wyndham Lake City I-75

Hampton Inn & Suites Lake City

2.5 star property
9.4 out of 10, Exceptional, (1002)
"It was a great stay "
The price is AU$177
includes taxes & fees
5 Oct - 6 Oct
Hampton Inn & Suites Lake City

Super 8 by Wyndham Lake City

2.0 star property
7.2 out of 10, Good, (642)
"Very friendly staff, delicious breakfast and dinner, clean pool, spacious room. Best hotel in the last 4 years within same price range"
The price is AU$114
includes taxes & fees
5 Oct - 6 Oct
Super 8 by Wyndham Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

Photo by Dr__Vlad
Open Photo by Dr__Vlad

Top O Brien Hotel Reviews

More cheap accommodation in O Brien

More cheap accommodation in O Brien

Frequently asked questions

Where is the best place to stay in O Brien?

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, located 29.9 mi (48.2 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Best Western Plus Lake City and Postcard Cabins Gilchrist Springs. See all available top hotels, or vacation rentals in O Brien.

What are some of the best holiday rentals that O Brien has to offer?

Enjoy semi-seclusion on the beautiful Suwannee River: This holiday home rental outside of O Brien is located on a river, and has a patio, a selection of games and a BBQ to put you at ease in your new surroundings. Kitchen amenities include a fridge, a stovetop and a microwave. See all vacation rentals in O Brien.

If I need to cancel my hotel reservation in O Brien, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.

What are some accommodation options with pools in O Brien?

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG: Features buffet, an outdoor pool and complimentary high-speed (wired) Internet access. Best Western Plus Lake City and La Quinta Inn & Suite by Wyndham Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.

How is it to stay in O Brien?

Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodation options to choose from. Find out more about O Brien.

What are the top places to visit in O Brien?

Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Wes Skiles Peacock Springs State Park and Lafayette Blue Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.

What's the seasonal weather in O Brien?

The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

Explore a world of travel with Expedia

Explore a world of travel with Expedia