Photo by Dr__Vlad

Search O Brien hotels

  • Plan, book, stay with confidence

    • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    today icon
    Change your mind
    Book hotels with free cancellation

Check prices for these dates

Tonight
23 Mar - 24 Mar
Tomorrow
24 Mar - 25 Mar
Next weekend
28 Mar - 30 Mar
In two weeks
4 Apr - 6 Apr

Filter by

Guest rating
Guest rating
Property class

Top hotels and accommodation in O Brien

Hampton Inn & Suites Alachua I-75
Reception

Hampton Inn & Suites Alachua I-75

2.5 star property
9.6 out of 10, Exceptional, (389)
"I like everything is my second time on that place and still same i love it i suggest to have options on the breakfast for not pork eaters other then that im really happy "
The price is AU$212
includes taxes & fees
20 Apr - 21 Apr
Hampton Inn & Suites Alachua I-75
Americas Best Value Inn Alachua
Desk, blackout curtains, iron/ironing board, rollaway beds

Americas Best Value Inn Alachua

2.0 star property
4.8 out of 10, (533)
"Property needs full renovation"
The price is AU$123
includes taxes & fees
24 Mar - 25 Mar
Americas Best Value Inn Alachua
Royal Inn
Property entrance

Royal Inn

2.0 star property
7.2 out of 10, Good, (169)
"It's a very old hotel but economically priced and the front desk employee, maybe owner, was very friendly and quick. The bathroom definitely needs updating or a better clean. We chose not to shower due to looking like mold. It may have been a stain as the rest of the room was clean. "
The price is AU$140
includes taxes & fees
24 Mar - 25 Mar
Royal Inn
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Exterior

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 star property
9.2 out of 10, Wonderful, (1002)
"Everything was great"
The price is AU$238
includes taxes & fees
13 Apr - 14 Apr
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Vista Verde Farm Retreat
Laptop workspace, free WiFi, bed sheets

Vista Verde Farm Retreat

2.0 star property
10.0 out of 10, Exceptional, (2)
"Park right next to the tiny home. It was clean and spacious. Bring a marshmallow/hotdog stick! "
The price is AU$302
includes taxes & fees
25 Mar - 26 Mar
Vista Verde Farm Retreat
BlueGem Motel
Reception

BlueGem Motel

2.0 star property
9.2 out of 10, Wonderful, (338)
"Nice and very clean "
The price is AU$182
includes taxes & fees
24 Mar - 25 Mar
BlueGem Motel
Palms Garden Inn
Premium bedding, desk, blackout curtains, soundproofing

Palms Garden Inn

2.0 star property
7.4 out of 10, Good, (525)
"We stayed for 1 night on a long trip, and it was comfortable and dog friendly with a nice big area to run around with the dog. We would definitely stay again."
The price is AU$120
includes taxes & fees
24 Mar - 25 Mar
Palms Garden Inn
The Blanche
Reception

The Blanche

2.0 star property
9.2 out of 10, Wonderful, (120)
"Beautiful historic property... very clean."
The price is AU$314
includes taxes & fees
24 Mar - 25 Mar
The Blanche
Days Inn by Wyndham Lake City I-10
Individually decorated, desk, laptop workspace, iron/ironing board

Days Inn by Wyndham Lake City I-10

2.0 star property
6.8 out of 10, (1000)
"Clean, well priced, close to interstate "
The price is AU$130
includes taxes & fees
25 Mar - 26 Mar
Days Inn by Wyndham Lake City I-10
Postcard Cabins Gilchrist Springs
Cabin, 1 Queen Bed

Postcard Cabins Gilchrist Springs

2.0 star property
10.0 out of 10, Exceptional, (7)
"Nice clean"
The price is AU$197
includes taxes & fees
10 Apr - 11 Apr
Postcard Cabins Gilchrist Springs
Super 8 by Wyndham Lake City
Exterior

Super 8 by Wyndham Lake City

2.0 star property
7.0 out of 10, Good, (597)
"Was able to book within five mins and right to my room "
The price is AU$158
includes taxes & fees
30 Mar - 31 Mar
Super 8 by Wyndham Lake City
Driftwood Inn
Soundproofing, bed sheets

Driftwood Inn

2.0 star property
7.8 out of 10, Good, (727)
"Nice, not great or amazing, but nice. Clean room and friendly staff."
The price is AU$129
includes taxes & fees
24 Mar - 25 Mar
Driftwood Inn
Regal Inn
Iron/ironing board, free WiFi, bed sheets

Regal Inn

2.5 star property
8.6 out of 10, Excellent, (477)
"Room was nice and clean. Lady on reception was very pleasant."
The price is AU$118
includes taxes & fees
6 Apr - 7 Apr
Regal Inn
Courtyard By Marriott Lake City
Terrace/patio

Courtyard By Marriott Lake City

3.0 star property
9.8 out of 10, Exceptional, (37)
"Great, new hotel! My only complaint is that (as of March 17, 2025) the restaurant isn’t actually open yet."
The price is AU$192
includes taxes & fees
6 Apr - 7 Apr
Courtyard By Marriott Lake City
Days Inn by Wyndham Lake City I-75
Pillow-top beds, in-room safe, desk, blackout curtains

Days Inn by Wyndham Lake City I-75

2.0 star property
7.4 out of 10, Good, (1004)
"Overall a very good not too pricey hotel. Nice updates to rooms. Only thing they forgot to upgrade was thwir towel racks. Just a bit rusty. Otherwise al good with a nice included breakfast!"
The price is AU$131
includes taxes & fees
30 Mar - 31 Mar
Days Inn by Wyndham Lake City I-75
Knights Inn Lake City
Lobby

Knights Inn Lake City

1.5 star property
5.4 out of 10, (603)
"Nice 👍🙂"
The price is AU$108
includes taxes & fees
24 Mar - 25 Mar
Knights Inn Lake City
Holiday Inn & Suites Lake City by IHG
Exterior

Holiday Inn & Suites Lake City by IHG

3.0 star property
8.4 out of 10, Very good, (1001)
"The hotel was so fresh and clean. The beds were amazing. Right across the street from Cracker barrell and I 75 super close. Love it"
The price is AU$181
includes taxes & fees
6 Apr - 7 Apr
Holiday Inn & Suites Lake City by IHG
Quality Inn Lake City
Exterior

Quality Inn Lake City

2.5 star property
7.8 out of 10, Good, (844)
"Very friendly staff, safe & clean environment. Pillows were hard & lumpy :( but everything else was great!"
The price is AU$144
includes taxes & fees
6 Apr - 7 Apr
Quality Inn Lake City
La Quinta Inn & Suite by Wyndham Lake City
Exterior

La Quinta Inn & Suite by Wyndham Lake City

2.5 star property
8.8 out of 10, Excellent, (1003)
"Very nice clean motel"
The price is AU$200
includes taxes & fees
26 Mar - 27 Mar
La Quinta Inn & Suite by Wyndham Lake City
Rodeway Inn Lake City I-75
Blackout curtains, free WiFi, bed sheets

Rodeway Inn Lake City I-75

2.0 star property
6.6 out of 10, (370)
"quite "
The price is AU$121
includes taxes & fees
30 Mar - 31 Mar
Rodeway Inn Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in O Brien
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Explore attractions like Suwannee River and Ichetucknee River as you discover things to see and do in O Brien.

See all hotels in O Brien
Photo by Dr__Vlad
Open Photo by Dr__Vlad

Frequently asked questions

Where is the best place to stay in O Brien?

La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Courtyard By Marriott Lake City and Americas Best Value Inn Lake City. See all available top hotels, or vacation rentals in O Brien.

What are some of the best holiday rentals that O Brien has to offer?

Pet-Friendly Florida Escape w/ Patio & Fire Pit!: This highly rated holiday home rental in O Brien offers a patio, a selection of games and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Some other homes for rent in O Brien include Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY. See all vacation rentals in O Brien.

If I need to cancel my hotel reservation in O Brien, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.

What's the best hotel for a romantic holiday to O Brien?

Your Safari on the Suwannee River is a favourite property for couples, and features in-room kitchens and private patios.

What's the best pet-friendly place to stay in O Brien?

Your Safari on the Suwannee River is a top property for people travelling with their pets and offers in-room kitchens for its human guests.

What are some accommodation options with pools in O Brien?

La Quinta Inn & Suite by Wyndham Lake City: Features on-the-go, an indoor pool and free self parking. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Courtyard By Marriott Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.

How is it to stay in O Brien?

Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 11 hotels and other accommodation options to choose from. Find out more about O Brien.

What are the top places to visit in O Brien?

Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Wes Skiles Peacock Springs State Park and Lafayette Blue Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.

What's the seasonal weather in O Brien?

The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.