Santa Ana Holidays from AU$5,586

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Your Santa Ana Holiday

Lock in a Santa Ana holiday package and prepare for an exciting adventure. Well known for its sunny weather and diversity, there's lots to love about this lively city. Fill up your itinerary with visits to Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama, some of the attractions you should see during your trip to Santa Ana. Browse Expedia's extensive range of travel options and start organising your dream holiday to Santa Ana today.

Top Holiday Package Deals in Santa Ana

Price found within the past 48 hours. Click for updated prices.
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was AU$6,239, price is now AU$5,586 per person
AU$5,586
per person
1 Jan - 8 Jan
found 3 hours ago
Return direct flight included
Sydney (SYD) to Panama City (PTY)
8.4/10 Very Good! (1,127 reviews)
Absolutely amazing property. 10/10 recommendations from me. Worth the stay.

Reviewed on 15 Oct 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was AU$8,439, price is now AU$6,289 per person
AU$6,289
per person
1 Jan - 8 Jan
found 3 hours ago
Return direct flight included
Sydney (SYD) to Panama City (PTY)
9/10 Wonderful! (1,005 reviews)
perfect location and city. Only comment is the supervisor, a short gentleman, is very aggressive and rude. Shoutout to Barbara, Rene and Jose.

Reviewed on 21 Oct 2025

Yoo by Wynwood House

Yoo by Wynwood House

4 out of 5
Calidonia
Price was AU$8,709, price is now AU$7,192 per person
AU$7,192
per person
1 Jan - 8 Jan
found 3 hours ago
Return direct flight included
Sydney (SYD) to Panama City (PTY)
9/10 Wonderful! (4 reviews)
Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about this. We still have not been contacted by anyone.

Reviewed on 26 July 2025

Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
Price was AU$8,409, price is now AU$7,173 per person
AU$7,173
per person
1 Jan - 8 Jan
found 3 hours ago
Return direct flight included
Sydney (SYD) to Panama City (PTY)
7.4/10 Good! (1,006 reviews)
Property and amenities were outdated with little effort to overcome those deficiencies through outstanding customer service. Options outside of costly renovations can and should be a part of the brand marketing and customer experience.

Reviewed on 21 Oct 2025

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
San Francisco
Price was AU$6,279, price is now AU$5,593 per person
AU$5,593
per person
1 Jan - 8 Jan
found 3 hours ago
Return direct flight included
Sydney (SYD) to Panama City (PTY)
9/10 Wonderful! (1,009 reviews)
All went well, except checkout. Only one receptionist for a huge waiting line for both check-in and checkout

Reviewed on 24 Oct 2025

Our guide on where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
Default Image

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Find hotels in Casco Viejo

Our pick of the best Santa Ana Hotel Deals

Casco View Apartments

Casco View Apartments

3.5 out of 5
C. 16 Oeste, Panama City, Provincia de Panamá
9.2/10 Wonderful! (48 reviews)
Great stay, would recommend.

Reviewed on 4 Sept 2025

Get rates
Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is AU$193 per night from 10 Nov to 11 Nov
AU$193
10 Nov - 11 Nov
includes taxes & fees
9/10 Wonderful! (4,418 reviews)
Room was clean, great staff and breakfast buffet

Reviewed on 24 Oct 2025

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
Fully refundable
The price is AU$204 per night from 2 Nov to 3 Nov
AU$204
2 Nov - 3 Nov
includes taxes & fees
8.4/10 Very Good! (2,265 reviews)
No comments

Reviewed on 23 Oct 2025

Crowne Plaza Panama Airport by IHG
See all 1,535 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
All Inclusive Holidays
Cheap Holidays
Cheap Holidays
Cheap Holidays
beach holidays
Beach Holidays
Beach Holidays

Frequently asked questions

How much does a Santa Ana holiday package cost?
From as little as AU$5,586. Yes, you read that correctly. Our Santa Ana holiday packages are an easy way to stretch your budget further. Combine your favourite hotels, flights and rental car and explore this destination your way.
How do I get a cheap travel package to Santa Ana?
One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Flights, hotels, activities and rental cars — we've got it all. Pick and choose the combination that best fits you and see your savings grow. We know a package deal is never a one-size-fits-all. That's why Expedia offers over 550 air carriers and 1 000 000 hotels throughout the world, which lets you customize your Santa Ana holiday.
Where should I stay in Santa Ana?
Most who travel to Santa Ana include both Miraflores Locks and Metropolitan Cathedral of Panama on their bucket lists. Why not go for a hotel right near these great attractions?
What are the top hotels in Santa Ana?
If it's your first time in Santa Ana, make a reservation at Hotel Riazor or Hotel Doral. Both hotels will make you feel at home and are favourites among lots of travellers.
How far in advance should I book my Santa Ana holiday?
While prices change from time to time, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to a year in advance. If circumstances have left you booking late, you might still be in luck. Low prices to Santa Ana sometimes occur only weeks before departure.
What does an Expedia Santa Ana travel package include?
That mostly depends on you. You can select from a range of Santa Ana packages, such as a rental car, flight and hotel. You can also book a hotel and a flight, or a rental car and a flight. Once you've made your booking, you can add on the fun stuff like tours and activities. Whatever your perfect Santa Ana break looks like, get set to save!
What should I know before booking a Santa Ana travel package?
Discover deals to suit your budget with an Expedia package. Hotels, airfares, rental cars — we've got everything you need to plan your getaway. You'll save big dollars just for bundling your bookings. Whether you're taking off on a ski trip or getting some sun on a warm beach, your ideal getaway is only clicks away.
Can I choose my airline with a Santa Ana Expedia holiday package?
Definitely. Expedia has more than 550 airline partners to pick from globally. With all that choice at your fingertips, finding the right carrier to get you to Santa Ana shouldn't be hard.
If I'm not able to travel, can I cancel my Santa Ana holiday package?
We totally get it — life can throw you the odd curveball. If you've booked a Santa Ana holiday package and have to amend or cancel it, we're here to help. It's always worth visiting our Customer Service Portal first for information. But generally, if you've booked your package in the last 24 hours, you may be able to amend or cancel your itinerary at no cost. If it's been longer than 24 hours, your hotel, airline or car rental company may charge a fee.

Discover the most popular places to visit in Santa Ana

Multiplaza Pacific Mall

Multiplaza Pacific Mall

During your trip to Panama City, you can search for that perfect souvenir at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Cinta Costera

Cinta Costera

Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera
Panama

Miraflores Locks

Learn about the local history of Ancon when you spend time at Miraflores Locks. Visit the shops and casinos in this vibrant area.

Miraflores Locks

Activities

Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

AU$76
per adult
96% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
The Panama Barcrawl - The OG Crawl

The Panama Barcrawl - The OG Crawl (Panama City, Panama)

AU$99
per adult
96% of travellers recommend
The Panama Barcrawl - The OG Crawl (Panama City, Panama)
Panama City: Poin Glass Observation Deck Ticket with VR Tour

Panama City: Poin Glass Observation Deck Ticket with VR Tour

AU$49
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.