Luxury Hotels & Resorts in São Tomé Island from AU$323

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Best São Tomé Island Luxury Hotels

Pestana São Tomé

5.0 star property
7.8 out of 10, Good, (63)
"-"
The price is AU$323
includes taxes & fees
29 Nov - 30 Nov
Pestana São Tomé
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Beautiful view of the beach with palm trees

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Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.

Frequently asked questions

Are you looking for a luxury hotel for your São Tomé Island holiday?
São Tomé Island has some interesting things to see and do including Amelia Lagoon and Pico São Tomé, so you might want to take in the local sights during your visit.
What's the best high-end hotel in São Tomé Island?
Pestana São Tomé is a luxury hotel with an ocean-view restaurant and private balconies, and it’s a popular choice for Expedia travellers looking for an elegant place to stay.
When can I expect good weather in São Tomé Island?
Planning for the weather is an important factor for making your trip to São Tomé Island a success, especially when you’re splurging. The hottest months are usually March and April, with an average temperature of 28°C, while the coldest months are July and August, with an average of 25°C. The rainiest months in São Tomé Island are November, October, December and April, with each month seeing an average of 249 mm of rainfall.
What's there to see and do in São Tomé Island?
Experience São Tomé Island and visit Amelia Lagoon, Pico São Tomé and Jale Beach. If you have a bit of extra time while you’re in the area, you might want to check out São Nicolau Waterfall and Cathedral of São Tomé.