Search Southeast Missouri hotels

Start date: Check-in selected.
To Date
End date: Check-out

    Change your mind

    Book hotels with free cancellation

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
24 Oct - 25 Oct
Tomorrow
25 Oct - 26 Oct
This weekend
24 Oct - 26 Oct
Next weekend
31 Oct - 2 Nov

Filter by

Guest rating
Guest rating
Star rating

Top hotels and accommodation in Southeast Missouri

Front of property
The Farmstead Hotel
The Farmstead Hotel
2.5 star property
8.8 out of 10, Excellent, (433)
"Very nice place to stay at."
United States
Edina
The price is AU$137
includes taxes & fees
29 Oct - 30 Oct
The Farmstead Hotel
Lobby
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MO
3.0 star property
9.6 out of 10, Exceptional, (1003)
"This was a wonderful stay. We will definitely stay again when we are in town!"
United States
Trista
The price is AU$146
includes taxes & fees
29 Oct - 30 Oct
Drury Inn & Suites Jackson MO
Exterior
Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHG
2.5 star property
9.2 out of 10, Wonderful, (523)
"Rooms were clean and everyone was really nice. Only thing I would say is that for the breakfast, the bacon wasn't quite all the way done other than that, a good experience."
United States
TEVIS
The price is AU$195
includes taxes & fees
9 Nov - 10 Nov
Holiday Inn Express & Suites Perryville by IHG
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
8.8 out of 10, Excellent, (641)
"We had a restful stay very safe & clean! Friendly staff:)"
United States
Rachel
The price is AU$140
includes taxes & fees
27 Oct - 28 Oct
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Exterior
Super 8 by Wyndham Farmington
Super 8 by Wyndham Farmington
2.0 star property
8.0 out of 10, Very good, (598)
"Clean, friendly staff, quiet"
United States
Stacy
The price is AU$97
includes taxes & fees
1 Nov - 2 Nov
Super 8 by Wyndham Farmington
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
9.6 out of 10, Exceptional, (1002)
"Great place"
United States
Eric
The price is AU$156
includes taxes & fees
9 Nov - 10 Nov
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby
Drury Inn & Suites Hayti Caruthersville
Drury Inn & Suites Hayti Caruthersville
3.0 star property
9.4 out of 10, Exceptional, (1000)
"Nice place for a over night stay would recamend."
United States
Terry
The price is AU$164
includes taxes & fees
2 Nov - 3 Nov
Drury Inn & Suites Hayti Caruthersville
Lobby
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
2.5 star property
9.0 out of 10, Wonderful, (1002)
"Close to the interstate so easy to get to when traveling. Nice property - plus that Outback Steakhouse is right next door for dining. We have stayed here numerous times over the years and always pleased. "
United States
Janice
The price is AU$121
includes taxes & fees
26 Oct - 27 Oct
Pear Tree Inn Cape Girardeau West
Free buffet breakfast
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
2.5 star property
9.4 out of 10, Exceptional, (686)
"Great place to stay!"
United States
Tracy
The price is AU$223
includes taxes & fees
2 Nov - 3 Nov
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Business centre
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
3.0 star property
9.4 out of 10, Exceptional, (1001)
"Everything nice clean and friendly"
United States
Megan
The price is AU$156
includes taxes & fees
30 Oct - 31 Oct
Drury Inn & Suites Cape Girardeau
Front of property
Echo Bluff State Park
Echo Bluff State Park
2.5 star property
9.4 out of 10, Exceptional, (210)
"Beautiful location…excellent service and facilities / grounds were clean and well kept."
United States
William
The price is AU$240
includes taxes & fees
25 Nov - 26 Nov
Echo Bluff State Park
Business centre
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
8.0 out of 10, Very good, (1003)
"Great location"
United States
Gregory
The price is AU$98
includes taxes & fees
1 Nov - 2 Nov
Baymont Inn and Suites by Wyndham Farmington, MO
Exterior
Super 8 by Wyndham Perryville
Super 8 by Wyndham Perryville
2.0 star property
8.4 out of 10, Very good, (922)
" Love the stay and staff was great "
United States
April
The price is AU$125
includes taxes & fees
5 Nov - 6 Nov
Super 8 by Wyndham Perryville
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
9.0 out of 10, Wonderful, (1001)
"Always enjoy our stay. Staff is very friendly, especially at breakfast! "
United States
Paul
The price is AU$121
includes taxes & fees
26 Oct - 27 Oct
Pear Tree Inn Cape Girardeau Near the Medical Center
Standard Room, 1 King Bed
Super 8 by Wyndham Potosi
Super 8 by Wyndham Potosi
2.0 star property
7.0 out of 10, Good, (370)
"The room was very good for the price."
United States
Benjamin
The price is AU$88
includes taxes & fees
28 Oct - 29 Oct
Super 8 by Wyndham Potosi
Lobby sitting area
Comfort Inn Festus - St Louis South
Comfort Inn Festus - St Louis South
2.5 star property
7.8 out of 10, Good, (895)
"The stay and food "
United States
Ricky
The price is AU$143
includes taxes & fees
2 Nov - 3 Nov
Comfort Inn Festus - St Louis South
Property amenity
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3.0 star property
9.4 out of 10, Exceptional, (1003)
"Very nice and quiet "
United States
Lana
The price is AU$159
includes taxes & fees
30 Oct - 31 Oct
Drury Inn & Suites Sikeston, MO
Lobby
Super 8 by Wyndham Bonne Terre
Super 8 by Wyndham Bonne Terre
2.0 star property
7.0 out of 10, Good, (525)
"Very nice facility. Room was clean and quiet."
United States
Jeffrey K.
The price is AU$96
includes taxes & fees
23 Nov - 24 Nov
Super 8 by Wyndham Bonne Terre
Lobby sitting area
The Riverview
The Riverview
4.0 star property
9.4 out of 10, Exceptional, (440)
"Location was perfect for family weekend!"
United States
Kelly
The price is AU$188
includes taxes & fees
27 Oct - 28 Oct
The Riverview
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:7 Nov - 9 Nov

Image gallery for Tiny Houses of French Village

House | Living area

Tiny Houses of French Village

2.5 star property
French Village
10/10Exceptional (3 reviews)
9% off
Price is AU$875
for 2 nights, 1 home
AU$438 per night
includes taxes & fees
Tiny Houses of French Village
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Central United States attractions

An old granite quarry that has filled with water. An beautiful spring hike around the lake got me this picture
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

4.8/5 (52 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties
Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
See properties

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

See all hotels in Southeast Missouri
The Current River flows through the Ozark National Scenic Riverway through the mountains of Missouri

Top Southeast Missouri Hotel Reviews

The Farmstead Hotel

The Farmstead Hotel

10/10 Excellent
"We enjoyed our stay . It was only for one night but we would go back again . The only thing the place there where they had to get drinks was pretty empty . Would Suggest filling it up more often . Overall very nice stay ! "
Richard 1-night trip
Posted 3 days ago
The Farmstead Hotel

More cheap accommodation in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St, Farmington, MO
The price is AU$98 per night from 1 Nov to 2 Nov
AU$98
1 Nov - 2 Nov
includes taxes & fees
8/10 Very Good! (1,019 reviews)

Explore a world of travel with Expedia