Cheap flights from Detroit to Palo Alto

View AU$242 flight on Mon, 9 Feb. 2026Opens in a new window

Popular airlines from Detroit to Palo Alto

  • Plan, book, fly with confidence

  • trending down icon
    Be in the know
    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon
    Book smarter
    Save up to 35% on select hotels after you book a flight*
  • payments icon
    Earn twice
    Earn your airline miles on top of our rewards
    Sign in

Cheap Flights from Detroit (DTT) to Palo Alto (SJC)

Prices were available within the past 7 days for one-way flights and round trip tickets for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Mon., 9 Feb. - Wed., 25 Feb.
DTW
Detroit
SFO
San Francisco
AU$453 Return, found 5 hours ago
AU$453
Return
found 5 hours ago
Select Delta flight, departing Mon., 9 Feb. from Detroit to San Francisco, returning Wed., 25 Feb., priced at AU$453 found 5 hours ago
American Airlines
Sat., 17 May - Sun., 25 May
DTW
Detroit
SFO
San Francisco
AU$467 Return, found 5 days ago
AU$467
Return
found 5 days ago
Select American Airlines flight, departing Sat., 17 May from Detroit to San Francisco, returning Sun., 25 May, priced at AU$467 found 5 days ago
American Airlines
Sat., 17 May - Sun., 25 May
DTW
Detroit
SFO
San Francisco
AU$475 Return, found 5 days ago
AU$475
Return
found 5 days ago
Select American Airlines flight, departing Sat., 17 May from Detroit to San Francisco, returning Sun., 25 May, priced at AU$475 found 5 days ago
American Airlines
Mon., 2 Jun. - Sat., 7 Jun.
DTW
Detroit
SFO
San Francisco
AU$482 Return, found 6 days ago
AU$482
Return
found 6 days ago
Select American Airlines flight, departing Mon., 2 Jun. from Detroit to San Francisco, returning Sat., 7 Jun., priced at AU$482 found 6 days ago
American Airlines
Fri., 13 Jun. - Fri., 20 Jun.
DTW
Detroit
SFO
San Francisco
AU$483 Return, found 5 hours ago
AU$483
Return
found 5 hours ago
Select American Airlines flight, departing Fri., 13 Jun. from Detroit to San Francisco, returning Fri., 20 Jun., priced at AU$483 found 5 hours ago
American Airlines
Wed., 11 Jun. - Sun., 29 Jun.
FNT
Flint
SFO
San Francisco
AU$485 Return, found 3 days ago
AU$485
Return
found 3 days ago
Select American Airlines flight, departing Wed., 11 Jun. from Flint to San Francisco, returning Sun., 29 Jun., priced at AU$485 found 3 days ago
*Available to Expedia members.