Cheap flights from Des Moines to Isla Holbox

View AU$359 flight on Mon, 16 Jun. 2025Opens in a new window

Popular airlines from Des Moines to Isla Holbox

  • Plan, book, fly with confidence

  • trending down icon
    Be in the know
    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon
    Book smarter
    Save up to 35% on select hotels after you book a flight*
  • payments icon
    Earn twice
    Earn your airline miles on top of our rewards
    Sign in

Cheap Flights from Des Moines (DSM) to Isla Holbox (CUN)

Prices were available within the past 7 days for one-way flights and round trip tickets for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Mon., 16 Jun. - Mon., 23 Jun.
DSM
Des Moines
CUN
Cancun
AU$731 Return, found 6 days ago
AU$731
Return
found 6 days ago
Select Delta flight, departing Mon., 16 Jun. from Des Moines to Cancun, returning Mon., 23 Jun., priced at AU$731 found 6 days ago
Delta
Mon., 16 Jun. - Mon., 23 Jun.
DSM
Des Moines
CUN
Cancun
AU$765 Return, found 6 days ago
AU$765
Return
found 6 days ago
Select Delta flight, departing Mon., 16 Jun. from Des Moines to Cancun, returning Mon., 23 Jun., priced at AU$765 found 6 days ago
United
Wed., 18 Jun. - Wed., 25 Jun.
DSM
Des Moines
CUN
Cancun
AU$765 Return, found 1 day ago
AU$765
Return
found 1 day ago
Select United flight, departing Wed., 18 Jun. from Des Moines to Cancun, returning Wed., 25 Jun., priced at AU$765 found 1 day ago
Aeromexico
Mon., 16 Jun. - Mon., 23 Jun.
DSM
Des Moines
CUN
Cancun
AU$775 Return, found 6 days ago
AU$775
Return
found 6 days ago
Select Aeromexico flight, departing Mon., 16 Jun. from Des Moines to Cancun, returning Mon., 23 Jun., priced at AU$775 found 6 days ago
Delta
Wed., 18 Jun. - Wed., 25 Jun.
DSM
Des Moines
CUN
Cancun
AU$797 Return, found 1 day ago
AU$797
Return
found 1 day ago
Select Delta flight, departing Wed., 18 Jun. from Des Moines to Cancun, returning Wed., 25 Jun., priced at AU$797 found 1 day ago
American Airlines
Mon., 16 Jun. - Mon., 23 Jun.
DSM
Des Moines
CUN
Cancun
AU$801 Return, found 6 days ago
AU$801
Return
found 6 days ago
Select American Airlines flight, departing Mon., 16 Jun. from Des Moines to Cancun, returning Mon., 23 Jun., priced at AU$801 found 6 days ago
*Available to Expedia members.