The Bocamina de San Ramón, located at the rear of the San Cayetano Temple in the historic mining district of Valenciana, holds a significant place in the history of Mexican mining. In 1549, the region became famous for the discovery of the richest silver mother lode in the world at the time, during the era of the Viceroyalty. This discovery sparked an economic boom, fuelling the development and growth of the surrounding area.

However, the mine is also remembered for a tragic event that occurred on the night of July 15, 1880. The waters of the nearby Santo Cristo shot suddenly cascaded into the Valenciana and San Ramón mines, causing a catastrophic explosion of pressure that launched miners, rocks, and scaffolding high into the air. This disaster became a symbol of mining catastrophes and marked the site in local memory.

The San Ramón mine was officially registered in 1775 by Ramón Luis de Aranda y Saavedra, further cementing its place in the rich mining history of Valenciana. Today, Bocamina de San Ramón is a poignant reminder of both the wealth and risks of the mining industry during its peak.