
Sikeston Holidays
Book a Hotel + Flight or Car together to unlock savings
Photo by Ryan Coleman
Your Sikeston Holiday
With a reputation for its rich history and rural countryside, Sikeston is an ideal getaway destination. Lock in one of our Sikeston holiday packages and discover all that this lively city has to offer. Fill your schedule with tours of The Book Bug, Sikeston Depot Museum and Central Park, some of the attractions you should see during a trip to Sikeston. Expedia can help you escape your routine. Tailor your holiday to Sikeston to suit your style of travel, whatever that may be!
Sikeston Holiday
Sikeston Essential Information
Language | English |
---|---|
Currency | U.S dollars |
Closest Airport | Cape Girardeau Municipal Airport (CGI) |
Population | 16,400 |
Max Temp Winter | 7ºC |
Max Temp Summer | 29ºC |
Top Sights | Sikeston Depot Museum, Central Park and The Book Bug |
Our pick of the best Sikeston Hotel Deals

Best Western Plus Sikeston
120 S Interstate Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is AU$143 per night from 24 Aug to 25 Aug
AU$143
24 Aug - 25 Aug
includes taxes & fees
8.2/10 Very Good! (1,004 reviews)
Two Thumbs Up
"It was awesome we would stay here again. The room was clean and the breakfast was pretty good for a continental the eggs weren’t great but everything else’s was good. We had a room that dogs were allowed in and it was very clean. Clean bathroom too. I even slept in the sheets so that’s telling you ..."
Reviewed on 19 Aug. 2025

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is AU$159 per night from 24 Aug to 25 Aug
AU$159
24 Aug - 25 Aug
includes taxes & fees
9.4/10 Exceptional! (1,005 reviews)
"The food options were great, the hotel was very clean, the staff were nice and friendly. The room was perfect and the bed was comfortable."
Reviewed on 18 Aug. 2025

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is AU$116 per night from 2 Sept to 3 Sept
AU$116
2 Sept - 3 Sept
includes taxes & fees
7.2/10 Good! (1,001 reviews)
"The staff were all great and happy to accommodate us when we asked to switch rooms due to an AC issue in our original room. The beds were comfortable and clean. No bugs in sight, which is a big thing for me when staying in hotels. Everything was very outdated, the rooms could definitely benefit from ..."
Reviewed on 8 Aug. 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
More holiday ideas
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.