Byron Holiday Rentals

  • Plan, book, stay with confidence
    • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    today icon
    Change your mind
    Book hotels with free cancellation

Holiday Rentals in Byron

The Berkman
Terrace/patio

The Berkman

3.0 star property
9.6 out of 10, Exceptional, (254)
"Clean & enjoyable stay. "
The price is AU$299
includes taxes & fees
26 Dec - 27 Dec
The Berkman
Broadway Plaza, Trademark Collection by Wyndham
Fridge, microwave, oven, stovetop

Broadway Plaza, Trademark Collection by Wyndham

3.0 star property
9.2 out of 10, Wonderful, (145)
"Great place to stay. Very handy for walking to the Mayo Clinic. Also very clean. Although we only stayed one night, it would be especially nice for longer stays as it really is a small apartment."
Broadway Plaza, Trademark Collection by Wyndham
Valley Cabin
Exterior

Valley Cabin

9.0 out of 10, Wonderful, (6)
"This is a great property. Peaceful, surrounded by fields & forests, birds singing, and fresh air. Wonderful parks and trails near by. Dan was a great host. I want to come back and stay in the fall and winter. This would also be a great place for a family get away"
The price is AU$208
includes taxes & fees
30 Nov - 1 Dec
Valley Cabin
Century Cottage-PERFECT for Mayo & downtown visitors!
Outdoor dining

Century Cottage-PERFECT for Mayo & downtown visitors!

10.0 out of 10, Exceptional, (101)
"We had a girls weekend and did some baking and shopping"
Century Cottage-PERFECT for Mayo & downtown visitors!
"Walden Pond" Adventure Amidst 44 Private Acres
Interior

"Walden Pond" Adventure Amidst 44 Private Acres

10.0 out of 10, Exceptional, (118)
"Really enjoyed the stay. It was very relaxing and a lot of fun"
"Walden Pond" Adventure Amidst 44 Private Acres
Lost Creek Executive Home on 200 acre horse Ranch w/Trout Stream
Fridge, microwave, oven, stovetop

Lost Creek Executive Home on 200 acre horse Ranch w/Trout Stream

9.8 out of 10, Exceptional, (6)
"This home was AMAZING and there was so much space. If it had more Beds, Futons or Couches available for LARGE GROUPS it could really bring in the bigger groups since the Mayo Civic Center is only 20 Minutes away. If you are looking for a great accommodating host and an amazing property...LOK NO FURTHER."
Lost Creek Executive Home on 200 acre horse Ranch w/Trout Stream
Park in the Garage and Walk to Mayo Clinic
Interior

Park in the Garage and Walk to Mayo Clinic

10.0 out of 10, Exceptional, (51)
"We stayed during medical visits at Mayo and enjoyed being able to walk to the clinic, come back and relax in such a comfortable place. Excellent communication from Jill, the owner, "
Park in the Garage and Walk to Mayo Clinic
BIG Discount! Five Star-3 Bedroom Showstopper 4 Minutes to Mayo Clinic!
Interior

BIG Discount! Five Star-3 Bedroom Showstopper 4 Minutes to Mayo Clinic!

9.6 out of 10, Exceptional, (8)
"We enjoyed our stay and appreciated how easy it was to reserve and communicate with the host! Thank you so much!"
BIG Discount! Five Star-3 Bedroom Showstopper 4 Minutes to Mayo Clinic!
Mayo Discount Offered-Family-Friendly 2 Level-Near Mayo
Interior

Mayo Discount Offered-Family-Friendly 2 Level-Near Mayo

8.2 out of 10, Very good, (18)
"Locked out of rental. Owner acknowledged that door lock freezes and locks people out some times. This is a safety issue for those that rent. Owner was quick to respond by having a friend come over and let me in. Black mold on ceiling, cobwebs on ceiling lights, dusty. Could not regulate heat in rental unit, very cold at night in rental. Owner was good to work with, but I should not have had to asked for the lock on door to work. Washer and dryer are a shared between residents in house. VERY...
Mayo Discount Offered-Family-Friendly 2 Level-Near Mayo
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆
Fridge, microwave, oven, stovetop

☆Dee Dee's Den: A Dharma Dwellings Parent Company☆

10.0 out of 10, Exceptional, (22)
"Every year my friends and family travel for a week. We are Combat Veterans, ranging from the Vietnam War to the Iraq and Afghanistan wars. This was the best house we have ever stayed in."
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆
Oasis Luxe Suite—Steps from Mayo Clinic Hospital
Fridge, microwave, oven, stovetop

Oasis Luxe Suite—Steps from Mayo Clinic Hospital

10.0 out of 10, Exceptional, (18)
"Clinic visits can be stressful to say the least. Oasis Luxe Suite made our evenings relaxing. Wonderful stay."
Oasis Luxe Suite—Steps from Mayo Clinic Hospital
Charming 2-Bedroom house along city trail 1 mile from Mayo Clinic and downtown.
Property grounds

Charming 2-Bedroom house along city trail 1 mile from Mayo Clinic and downtown.

9.8 out of 10, Exceptional, (37)
"We stayed in this cute little house for 7 weeks in the summertime. The property is well-maintained, very clean and nicely decorated. It had everything we needed from A/C to laundry to wi-fi. The recliner chair is very comfortable. The attic space was cozy and great for visiting guests. Neighborhood felt safe and was generally quiet. The walking paths, back deck and creek views make this place a sanctuary despite being close to downtown. Access to Mayo was quick and easy. The owners were...
Charming 2-Bedroom house along city trail 1 mile from Mayo Clinic and downtown.
Newly remodeled "Beach" Themed home that is close to downtown and Mayo Clinic.
Fridge, microwave, oven, stovetop

Newly remodeled "Beach" Themed home that is close to downtown and Mayo Clinic.

10.0 out of 10, Exceptional, (1)
"I booked for a stay for appts at Mayo. There were just two of us. The home is well situated for Mayo it’s a quick trip!! It’s also well located in terms of needing to run for coffee, restaurants, to the grocery store…etc. all things we found near. The home is very organized, clutter free and cheerfully decorated in bright colors. It’s equipped with modern lighting, heating and sound systems. The floors are heated in the basement and bathroom which was lovely!! The kitchen is well equipped and...
Newly remodeled "Beach" Themed home that is close to downtown and Mayo Clinic.
Lovely 2 bedroom apartment near St Mary's Hospital
Private kitchen

Lovely 2 bedroom apartment near St Mary's Hospital

8.6 out of 10, Excellent, (10)
"Was a great space to stay, work remotely, and receive treatment at Mayo clinic. Close to charming creek trail. Walking distance to stores and restaurants and Mayo."
Lovely 2 bedroom apartment near St Mary's Hospital
Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.
Fridge, microwave, oven, stovetop

Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.

10.0 out of 10, Exceptional, (57)
"One of the best VRBOs we have stayed in and for sure the cleanest. This home is lovely, decorated beautifully and supplied with everything we needed. We had several appointments at St. Mary’s Hospital and the Mayo/Gonda buildings. This home was conveniently located between the two and walkable to both.. Restaurants and grocery stores nearby and off-street parking. Hosts were very responsive and accommodating. We’ll stay here again."
Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.
Silver Lake Oasis
Miscellaneous

Silver Lake Oasis

9.6 out of 10, Exceptional, (33)
"Cozy, mostly modern, except for the bathroom. Steep stairs to the bedroom. Love the location. Made a few casts from shore, but didn't catch any fish. Walk around to the lakefront a bit steep and unsteady. Otherwise, enjoyed our stay!"
Silver Lake Oasis
Mayo Discount Available- 2Bedroom Close to Mayo
Fridge, microwave, oven, stovetop

Mayo Discount Available- 2Bedroom Close to Mayo

8.8 out of 10, Excellent, (20)
"This was a great location in relation to the Mayo. I wish you would do something about the steps up to the unit. The gutter over the bottom step leaks and drips on that bottom step. It froze over night and when I went out the next morning I slipped on that step. I was able to catch myself but someone else might not. It was adequate for our needs. The landlord was very receptive to our needs. One last thing was the TV is not hooked up to anything so it was of no use. Overall for the price it was...
Mayo Discount Available- 2Bedroom Close to Mayo
BIG Discount 2 Bedroom Oasis 5 Minutes to Mayo Clinic!
Fridge, microwave, oven, stovetop

BIG Discount 2 Bedroom Oasis 5 Minutes to Mayo Clinic!

10.0 out of 10, Exceptional, (9)
"Location was great for what we needed. Everything about the property was exactly as described and perfect for our short stay."
The price is AU$344
includes taxes & fees
30 Nov - 1 Dec
BIG Discount 2 Bedroom Oasis 5 Minutes to Mayo Clinic!
Great Family Home, Fenced Yard, Pet Friendly, 2 mi from Mayo
Fridge, microwave, oven, stovetop

Great Family Home, Fenced Yard, Pet Friendly, 2 mi from Mayo

10.0 out of 10, Exceptional, (29)
"Perfect location for the wedding we were attending. House was clean and in a nice neighborhood. Primary bedroom did not have a king bed. Queen bed was okay but should be replaced due to the dip in the middle. "
Great Family Home, Fenced Yard, Pet Friendly, 2 mi from Mayo
Upscale King Suite—Steps from Mayo Clinic Hospital
Fridge, microwave, oven, stovetop

Upscale King Suite—Steps from Mayo Clinic Hospital

10.0 out of 10, Exceptional, (16)
"Convient, clean and accomidating."
Upscale King Suite—Steps from Mayo Clinic Hospital
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Byron
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Other types of properties in Byron you may be interested in

Kahler Grand Hotel
Indoor pool

Kahler Grand Hotel

3.0 star property
8.2 out of 10, Very good, (1199)
"There are obvious signs of neglect, like the signs by the elevators that say fitness center on level M except on level M where the signs say fitness is in level 11. That took me twenty minutes to figure out. They are on level M, lol. "
The price is AU$265
includes taxes & fees
27 Nov - 28 Nov
Kahler Grand Hotel
Med City Inn & Suites - Mayo Clinic Area
Desk, laptop workspace, iron/ironing board, free WiFi

Med City Inn & Suites - Mayo Clinic Area

2.5 star property
7.8 out of 10, Good, (1043)
"The bed sheets and bathroom were pretty clean. Carpet in rooms are gross and property outdated. For the price it was good. The staff was great! Breakfast was same everyday but not terrible"
The price is AU$133
includes taxes & fees
26 Dec - 27 Dec
Med City Inn & Suites - Mayo Clinic Area
AmericInn by Wyndham Rochester Near Mayo Clinic
Serves lunch, dinner and happy hour

AmericInn by Wyndham Rochester Near Mayo Clinic

3.0 star property
8.0 out of 10, Very good, (617)
"The check-in personnel was very friendly and informative about the facility without having to ask. A restaurant is connected which makes it very convenient. Not far from then Mayo Clinic."
The price is AU$131
includes taxes & fees
26 Dec - 27 Dec
AmericInn by Wyndham Rochester Near Mayo Clinic
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.
Unlock Black Friday deals

Frequently asked questions

Can I find holiday rentals in Byron?

Yes, there are holiday rentals close to the most popular sights in Byron, or you can select a more secluded option if you're looking for a relaxing stay. Byron is known for its zoo and golf courses. Make sure you have time to check out the bars and parks during your trip.

What are some of the best holiday rentals that Byron has to offer?

"Walden Pond" Adventure Amidst 44 Private Acres: This holiday home rental outside of Byron is located on a river, and has a fireplace, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games.

What’s there to see and do in Byron?

While exploring the area, visit family-friendly sights like Minnesota Children's Museum, or get outside and enjoy nature at Oxbow Park. Salem Glen Winery and Apache Mall are a couple of places you'll find in the wider area.

What’s a holiday rental in Byron like?

Holiday rentals are private properties where you can stay for a few weeks, or just a few days, in Byron. Holiday rentals feature amenities such as laundry facilities and kitchens so you'll have a home away from home. If you're concerned about cleanliness, a holiday rental can provide a sense of privacy away from public hotel lifts and busy front desks while still allowing you the enjoyment of travel. You'll also have more space in a holiday rental than in a hotel, which is another reason why a holiday rental is a popular option for family trips or small group gatherings.