Search North Santee hotels

  • Plan, book, stay with confidence
    • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    today icon
    Change your mind
    Book hotels with free cancellation

Check North Santee hotel prices

Tonight
25 Nov - 26 Nov
Tomorrow night
26 Nov - 27 Nov
This weekend
29 Nov - 1 Dec
Next weekend
6 Dec - 8 Dec

Filter by

Guest rating
Guest rating
Property class

Top hotels and accommodation in North Santee

Adorable 2 story lake front setting.
Exterior

Adorable 2 story lake front setting.

9.6 out of 10, Exceptional, (8)
"Enjoyed our stay, and Brandi the dog. "
Adorable 2 story lake front setting.
Pet-Friendly Santee River Retreat w/ Private Dock!
Property grounds

Pet-Friendly Santee River Retreat w/ Private Dock!

9.8 out of 10, Exceptional, (34)
"Loved the property!"
Pet-Friendly Santee River Retreat w/ Private Dock!
Pet-friendly Santee River Retreat w/ Private Dock!
Miscellaneous

Pet-friendly Santee River Retreat w/ Private Dock!

3.0 star property
Pet-friendly Santee River Retreat w/ Private Dock!
FOR SALE/Peaceful Waterfront 3-bedroom Villa in Belle Isle Yacht Club Georgetown
Miscellaneous

FOR SALE/Peaceful Waterfront 3-bedroom Villa in Belle Isle Yacht Club Georgetown

FOR SALE/Peaceful Waterfront 3-bedroom Villa in Belle Isle Yacht Club Georgetown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in North Santee
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.
Unlock Black Friday deals

Frequently asked questions

What's the best place for a stay in North Santee?

Quality Inn & Suites, located 18 mi (28.9 km) from the heart of North Santee, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Hampton Inn Georgetown-Marina and The George Hotel. See all available top hotels, or vacation rentals in North Santee.

What are some of the best holiday rentals that North Santee has to offer?

Incredible Oceanfront Retreat in Pawleys Island with Private Dock on Creek: This holiday home rental outside of North Santee is located on the beach, and has a fireplace, a balcony and a BBQ to put you at ease in your new surroundings. It has 4 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. See all vacation rentals in North Santee.

If I need to cancel my hotel reservation in North Santee, will I receive a refund?

Yes, most hotel reservations are refundable if you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in North Santee.

What are some accommodation options with pools in North Santee?

Hampton Inn Georgetown - Marina: Features a snack bar, a pool and free breakfast. Quality Inn & Suites and Quality Inn & Suites are a couple of other choices that feature an on-site pool. View all hotels with pools in North Santee.

What is staying in North Santee like?

Visitors will definitely enjoy all that North Santee has to offer. There are 316 hotels and other accommodation options in the surrounding area. Find out more about North Santee.

What are the top places to visit in North Santee?

Places to visit in the wider area include Hobcaw Barony, Rice Museum and North Island Beach. You'll also find DeBordieu Beach and Hopsewee Plantation in the area. Take a look at what more there is to see and do in Expedia's North Santee guide.

What's the seasonal weather like in North Santee?

The hottest months are usually July and August, with an average temperature of 26°C, while the coldest months are January and February, with an average of 12°C. The rainiest months in North Santee are August, July, September and June, with each month seeing an average of 186 mm of rainfall.