Otay Mesa Hotels, San Diego

  • Plan, book, stay with confidence
  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

4451 Cheap Hotels in Otay Mesa - Specials, Reviews, & Last Minute Deals

Best Western Plus Marina Gateway Hotel

3.5 star property
9.0 out of 10, Wonderful, (2952)
"Very clean"
The price is AU$227
includes taxes & fees
1 Dec - 2 Dec
Best Western Plus Marina Gateway Hotel

Rosarito Beach Hotel

3.0 star property
8.0 out of 10, Very good, (1056)
"This place was amazing and really close to the beach, pools available, clean overall really nice "
The price is AU$189
includes taxes & fees
25 Nov - 26 Nov
Rosarito Beach Hotel

Grand Hotel Tijuana

3.5 star property
9.0 out of 10, Wonderful, (2959)
"The accomudation was a very nice full service hotel. The staff was very polite and helpful."
The price is AU$187
includes taxes & fees
1 Dec - 2 Dec
Grand Hotel Tijuana

Loews Coronado Bay Resort

4.0 star property
8.6 out of 10, Excellent, (1017)
"Surprisingly reasonable price to stay on Coronado, away from the hullabaloo but a quick drive to the Village or San Diego. Nice, comfortable rooms, fairly upscale property. We'd love to come back!"
The price is AU$375
includes taxes & fees
15 Dec - 16 Dec
Loews Coronado Bay Resort

SureStay Hotel by Best Western Chula Vista San Diego Bay

3.0 star property
7.6 out of 10, Good, (1302)
"No complaints. Only thing I would like to see in ALL hotels is a small pack of disinfectant wipes so each guest has the ability to wipe down ( disinfect) knobs and remote control. "
The price is AU$130
includes taxes & fees
17 Dec - 18 Dec
SureStay Hotel by Best Western Chula Vista San Diego Bay

Hotel Festival Plaza Playas Rosarito

3.0 star property
7.2 out of 10, Good, (1362)
"Great Service Great Experience…"
The price is AU$137
includes taxes & fees
25 Nov - 26 Nov
Hotel Festival Plaza Playas Rosarito

The Rambler Motel

3.0 star property
9.0 out of 10, Wonderful, (1864)
"Very basic facility. No fridge and kettle in room. But it is quite and comfortable bed and pillows. "
The price is AU$176
includes taxes & fees
25 Nov - 26 Nov
The Rambler Motel

Hotel Wellintown

3.0 star property
9.2 out of 10, Wonderful, (634)
"My favorite hotel in Tijuana "
The price is AU$122
includes taxes & fees
27 Nov - 28 Nov
Hotel Wellintown

Hotel Corona Plaza

3.0 star property
6.6 out of 10, (1482)
"Always a pleasure staying at this hotel . Complimentary breakfast is delicious. Staff is always friendly and helpful "
The price is AU$101
includes taxes & fees
9 Dec - 10 Dec
Hotel Corona Plaza

Hotel West Plaza

3.0 star property
9.4 out of 10, Exceptional, (309)
"👌"
The price is AU$131
includes taxes & fees
27 Nov - 28 Nov
Hotel West Plaza

Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel

2.5 star property
7.4 out of 10, Good, (1337)
"Good quiet convenient "
The price is AU$185
includes taxes & fees
15 Dec - 16 Dec
Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel

Real Inn Tijuana by Camino Real Hotels

4.5 star property
8.6 out of 10, Excellent, (1716)
"Great place to stay."
The price is AU$168
includes taxes & fees
1 Dec - 2 Dec
Real Inn Tijuana by Camino Real Hotels

Quartz Hotel & SPA

4.5 star property
9.2 out of 10, Wonderful, (1020)
"The service is the best! People are incredibly attentive in everything! It's my second time there and both times I've had the best experience…"
The price is AU$278
includes taxes & fees
25 Nov - 26 Nov
Quartz Hotel & SPA

Hotel Lucerna Tijuana

4.5 star property
8.6 out of 10, Excellent, (1020)
"Every was excellent "
The price is AU$226
includes taxes & fees
16 Dec - 17 Dec
Hotel Lucerna Tijuana

Ibis Tijuana Zona Rio

3.0 star property
8.4 out of 10, Very good, (1513)
"Great location, really clean and close to everything but the rooms are very small. "
The price is AU$122
includes taxes & fees
9 Dec - 10 Dec
Ibis Tijuana Zona Rio

Hercor Hotel - Urban Boutique

3.0 star property
8.4 out of 10, Very good, (1062)
"Very confortable "
The price is AU$175
includes taxes & fees
8 Dec - 9 Dec
Hercor Hotel - Urban Boutique

Hotel Ticuán

3.5 star property
9.0 out of 10, Wonderful, (1936)
"perfect "
The price is AU$148
includes taxes & fees
5 Dec - 6 Dec
Hotel Ticuán

Studio 6 Suites San Ysidro, CA -San Diego South Bay

2.5 star property
7.6 out of 10, Good, (722)
"Always an affordable, pleasant option. Clean rooms, mine had an updated shower."
The price is AU$121
includes taxes & fees
15 Dec - 16 Dec
Studio 6 Suites San Ysidro, CA -San Diego South Bay

Del Mar Inn Rosarito

3.0 star property
8.0 out of 10, Very good, (1001)
"Good"
The price is AU$134
includes taxes & fees
8 Dec - 9 Dec
Del Mar Inn Rosarito

Hotel Grand One Plaza

3.0 star property
8.6 out of 10, Excellent, (941)
"I love the terrazzo,the top of building it gourgeos 😍😍😍"
The price is AU$108
includes taxes & fees
1 Dec - 2 Dec
Hotel Grand One Plaza
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Otay Mesa
Save an average of 15% on thousands of hotels when you're signed in
Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.

Frequently asked questions

What's it like in Otay Mesa?

Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on Expedia customer reviews, Quality Suites San Diego Otay Mesa is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel.

How many hotels will I find in the Otay Mesa area?

Expedia has 5 Otay Mesa hotels and other accommodation options, and one might make a good home base for venturing out into the greater San Diego area.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! Most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.

What is there to do in this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.