Photo by Erdem Yücel

Luxury Hotels & Resorts in Pythagorio

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Best Pythagorio Luxury Hotels

Doryssa Seaside Resort

5.0 star property
8.6 out of 10, Excellent, (125)
"Great location and close to town. Great breakfast and friendly staff. Property is run down and is in urgent need of refurbishing. Otherwise, would highly recommend it."
Doryssa Seaside Resort

Proteas Blu Resort - Adults Only

5.0 star property
9.4 out of 10, Exceptional, (60)
"Εξαιρετικό ξενοδοχείο το οποίο από όλες τις πτυχές αγγίζει την τελειότητα. Από καθαριότητα, τοποθεσία, ποιότητα φαγητού και υπηρεσιών, το Proteas Blu έχει ανταποκριθεί στις προσδοκίες μας στο 100%!"
Proteas Blu Resort - Adults Only
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.

Frequently asked questions

Are you searching for the perfect hotel for your luxury trip to Pythagorio?
During your visit, you might want to enjoy the port which Pythagorio is known for.
What's the best luxury hotel in Pythagorio?
Casa Cook Samos is a luxury hotel with a beachfront restaurant and 2 bars, and it’s a popular choice for Expedia travellers looking for an elegant place to stay. Doryssa Seaside Resort and Proteas Blu Resort - Adults Only are other upscale choices for your trip.
How many luxury hotels will I be able to find in Pythagorio?
Lie in the lap of luxury during your getaway to Pythagorio in one of Expedia’s 5 luxury hotels.
When can I expect good weather in Pythagorio?
Planning for the weather is an important factor for making your trip to Pythagorio a success, especially when you’re splurging. The hottest months are usually August and July, with an average temperature of 25°C, while the coldest months are January and February, with an average of 13°C. Average annual precipitation for Pythagorio is 837 mm.
What's there to see and do in Pythagorio?
Experience Pythagorio with a stop at Samos Pythagorion Archaeological Museum, Pythagoreion and Glicorisa Beach. If you have spare time during your trip, you might want to make a stop at Mykali Beach and Folklore Museum of the Nikolaos Dimitriou Foundation of Samos.