Search Santa Cruz hotels

  • Plan, book, stay with confidence
  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Check Santa Cruz hotel prices

Tomorrow night
Next weekend

Filter by

Guest rating
Guest rating
Property class

Top hotels and accommodation in Santa Cruz

Casa Candela

3.5 star property
8.8 out of 10, Excellent, (69)
"Excellent service "
The price is AU$216
includes taxes & fees
25 Nov - 26 Nov
Casa Candela

Hotel Perlatto

3.5 star property
7.4 out of 10, Good, (35)
"very good staff "
The price is AU$24
includes taxes & fees
26 Nov - 27 Nov
Hotel Perlatto

Hotel Boutique Al Alma

4.5 star property
9.6 out of 10, Exceptional, (24)
"Cozy, clean and quaint, colonnial style "
Hotel Boutique Al Alma

Hotel Mariscal Robledo

3.0 star property
9.4 out of 10, Exceptional, (198)
"The staff was amazing. "
The price is AU$114
includes taxes & fees
28 Nov - 29 Nov
Hotel Mariscal Robledo

Alma Nativa

5.0 star property
The price is AU$157
includes taxes & fees
25 Nov - 26 Nov
Alma Nativa

Hotel Quimbaya

3.0 star property
9.0 out of 10, Wonderful, (22)
"Amazing Staff. Beautiful location. Food is so good. Family friendly. And romantic."
The price is AU$113
includes taxes & fees
25 Nov - 26 Nov
Hotel Quimbaya

Hotel Porton del Sol

3.0 star property
9.6 out of 10, Exceptional, (7)
"I’ll give 5 stars to AXL. He was awesome, friendly, always helpful and super nice 😃👍. "
The price is AU$80
includes taxes & fees
25 Nov - 26 Nov
Hotel Porton del Sol

Hotel San Sebastian del Tonusco

3.0 star property
9.0 out of 10, Wonderful, (29)
"Amazing stay Amazing staff Amazing location."
The price is AU$78
includes taxes & fees
25 Nov - 26 Nov
Hotel San Sebastian del Tonusco

Nativa Refugio Escondido

4.5 star property
6.6 out of 10, (4)
"I booked here Sunday night. Right after dinner I followed my gps to the address. It put me in area of San Nicolas. I drove around for a hour looking for it but couldn’t find it. I reached out to the hotel but they didn’t answer there phone. I asked door people at nearby properties none of them heard of it. I got frustrated drove home. They refuse to refund the money on two rooms. Avoid this place at all costs. I’m not even sure if it exists. They are heartless. That don’t answer...
The price is AU$136
includes taxes & fees
25 Nov - 26 Nov
Nativa Refugio Escondido

Hosteria Tonusco Campestre

3.0 star property
8.8 out of 10, Excellent, (23)
"It’s a very tropical area with many trees,gardens,tropical vegetation and mosquitoes if it rains.It’s near the central area but you can take a mototaxi for just US$1. The swimming pool is good and there are many other activities to do there but the best it’s walking all around the Colonial Area. Good restaurants, museums, churches and if you go for a cultural event it will be even better."
The price is AU$83
includes taxes & fees
25 Nov - 26 Nov
Hosteria Tonusco Campestre

Espectacular Finca en Tierra Caliente cerca a Medellin

Espectacular Finca en Tierra Caliente cerca a Medellin

Cautiva Hotel

3.0 star property
10.0 out of 10, Exceptional, (2)
"Like the name, we were captivated by this property, a jewel."
Cautiva Hotel

Hotel Tropical San Jeronimo

2.5 star property
The price is AU$54
includes taxes & fees
1 Dec - 2 Dec
Hotel Tropical San Jeronimo

Casa Bixa Hotel Boutique - Adults only

3.5 star property
10.0 out of 10, Exceptional, (39)
"Excellent "
The price is AU$169
includes taxes & fees
25 Nov - 26 Nov
Casa Bixa Hotel Boutique - Adults only

La Selva Hotel San Jeronimo

2.5 star property
9.0 out of 10, Wonderful, (2)
"Un lugar muy bonito, cómodo de buen clima y excelente atención. Comida casera muy rica."
The price is AU$56
includes taxes & fees
25 Nov - 26 Nov
La Selva Hotel San Jeronimo

HOTEL KALMA

3.5 star property
10.0 out of 10, Exceptional, (4)
"Excellent"
The price is AU$239
includes taxes & fees
30 Nov - 1 Dec
HOTEL KALMA

Hotel Pueblito Viejo

3.0 star property
6.0 out of 10, (2)
"Very nice staff, always willing to help!!"
The price is AU$97
includes taxes & fees
25 Nov - 26 Nov
Hotel Pueblito Viejo

Hotel Villa Alicia

2.5 star property
7.0 out of 10, Good, (4)
"A lot of nature around the farm Villa Alicia, nice pool and jacuzzi, good price, good place for friends or family reunions, nice rooms,"
The price is AU$47
includes taxes & fees
25 Nov - 26 Nov
Hotel Villa Alicia

Libertg Hotels

3.5 star property
10.0 out of 10, Exceptional, (1)
"La atención fue inmejorable, la comida deliciosa, los espacios comunes muy bien mantenidos, con mcuhas ganas de volver totalmente"
The price is AU$160
includes taxes & fees
8 Dec - 9 Dec
Libertg Hotels

Finca Hotel La Estancia

3.0 star property
6.0 out of 10, (1)
"Un buen lugar pero ponen muy alto el volumen de la musica en la piscina, tambien si deseas salir en la noche del hotel no encuentra como solicitar la apertura de la puerta"
The price is AU$89
includes taxes & fees
30 Nov - 1 Dec
Finca Hotel La Estancia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Santa Cruz
Save an average of 15% on thousands of hotels when you're signed in
Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.

Frequently asked questions

Where is the best place to stay in Santa Cruz?

Located 4 mi (6.5 km) from the heart of Santa Cruz, Hotel Dorado La 70 is a top choice for your stay, based on our traveller data. Two other options for your stay in the area are Novotel Medellín El Tesoro and York Luxury Suites Medellín. See all available top hotels, or vacation rentals in Santa Cruz.

What are some of the best holiday rentals that Santa Cruz has to offer?

Increible Casa con Jacuzzi en Poblado-lleras: This holiday home rental outside of Santa Cruz is equipped with 1 hot tub, air conditioning and laundry facilities to help you feel comfortable during your stay. It has 4 bedrooms, as well as a kitchen with a fridge, a microwave and a coffee maker, so that you can cook with friends or family. See all vacation rentals in Santa Cruz.

If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?

Yes! Most hotel bookings are fully refundable if you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might be able to cancel it and receive a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.

What are some hotels with pools in Santa Cruz?

Novotel Medellín El Tesoro: 4-star hotel located near El Tesoro Shopping Park. Features a rooftop terrace, a pool and free self-parking. NH Collection Medellín Royal and The Click Clack Hotel Medellin are two additional hotels with an on-site pool. View all hotels with pools in Santa Cruz.

What is staying in Santa Cruz like?

Visitors will definitely enjoy all that Santa Cruz has to offer. In Santa Cruz, there are 2 hotels and other accommodation options to choose from. Find out more about Santa Cruz.

What should I do while I'm visiting Santa Cruz?

Places to visit in the wider area include Medellin Botanical Garden, Explora Park and Arvi Park. You'll also find Antioquia Museum and Botero Plaza in the area. Take a look at what more there is to see and do in Expedia's Santa Cruz guide.

What's the seasonal weather in Santa Cruz?

The hottest months are usually August and July, with an average temperature of 19°C, while the coldest months are December and January, with an average of 18°C. The rainiest months in Santa Cruz are May, April, October and November, with each month seeing an average of 406 mm of rainfall.