Holiday Homes in Byron

  • Plan, book, stay with confidence
    • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    today icon
    Change your mind
    Book hotels with free cancellation

Featured Holiday Homes in Byron

Downtown rambler. 2 bed, 1 bath, office & fence.
Outdoor dining

Downtown rambler. 2 bed, 1 bath, office & fence.

The price is AU$488
includes taxes & fees
1 Dec - 2 Dec
Downtown rambler. 2 bed, 1 bath, office & fence.
Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.
Fridge, microwave, oven, stovetop

Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.

10.0 out of 10, Exceptional, (57)
"One of the best VRBOs we have stayed in and for sure the cleanest. This home is lovely, decorated beautifully and supplied with everything we needed. We had several appointments at St. Mary’s Hospital and the Mayo/Gonda buildings. This home was conveniently located between the two and walkable to both.. Restaurants and grocery stores nearby and off-street parking. Hosts were very responsive and accommodating. We’ll stay here again."
Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.
Park in the Garage and Walk to Mayo Clinic
Interior

Park in the Garage and Walk to Mayo Clinic

10.0 out of 10, Exceptional, (51)
"We stayed during medical visits at Mayo and enjoyed being able to walk to the clinic, come back and relax in such a comfortable place. Excellent communication from Jill, the owner, "
Park in the Garage and Walk to Mayo Clinic
Elegant Home w/ Deck, 5 Blocks to Mayo Clinic
Exterior

Elegant Home w/ Deck, 5 Blocks to Mayo Clinic

9.8 out of 10, Exceptional, (8)
"Convenient location to Mayo Clinic, comfortable, and well stocked for our week stay."
Elegant Home w/ Deck, 5 Blocks to Mayo Clinic
Luxury Stay/ Theater / Pool Table / Dogs Welcome
Fridge, microwave, stovetop, coffee/tea maker

Luxury Stay/ Theater / Pool Table / Dogs Welcome

2.0 star property
Luxury Stay/ Theater / Pool Table / Dogs Welcome
"Walden Pond" Adventure Amidst 44 Private Acres
Interior

"Walden Pond" Adventure Amidst 44 Private Acres

10.0 out of 10, Exceptional, (118)
"Really enjoyed the stay. It was very relaxing and a lot of fun"
"Walden Pond" Adventure Amidst 44 Private Acres
BIG Discount! Five Star-3 Bedroom Showstopper 4 Minutes to Mayo Clinic!
Interior

BIG Discount! Five Star-3 Bedroom Showstopper 4 Minutes to Mayo Clinic!

9.6 out of 10, Exceptional, (8)
"We enjoyed our stay and appreciated how easy it was to reserve and communicate with the host! Thank you so much!"
BIG Discount! Five Star-3 Bedroom Showstopper 4 Minutes to Mayo Clinic!
Fresh space near Mayo Clinic and downtown
Microwave, dishwasher, coffee/tea maker, cookware/dishes/utensils

Fresh space near Mayo Clinic and downtown

9.6 out of 10, Exceptional, (16)
"Very clean property. It was comfortable and cute. The owners were responsive to us and so helpful"
Fresh space near Mayo Clinic and downtown
Delightful family home near pool, playground, park, nature center 1.6 mi to Mayo
Smart TV, video games, ping pong, books

Delightful family home near pool, playground, park, nature center 1.6 mi to Mayo

10.0 out of 10, Exceptional, (23)
"A family member had several day appointments at the Mayo. He has mobility iaauws. Thia home eas perfect. 1 level. Walk-in shower. Bed with head and feet incline."
Delightful family home near pool, playground, park, nature center 1.6 mi to Mayo
2023 Construction, 5 BR, Gym, Game Area
Property grounds

2023 Construction, 5 BR, Gym, Game Area

10.0 out of 10, Exceptional, (14)
"AMAZING!!!! Every single thing about this property/ stay was far above and beyond our expectations. The house is amazing. The photos are totally accurate, but still don’t do it justice. We were in town for our dad’s 95th birthday. Our children/grandchildren live in 4 different states. All were able to come for the weekend and the house accommodated all of us, in every age category. Pamela went the “extra mile” in every aspect of this property from laundry pods to coffee to hair dryers to...
2023 Construction, 5 BR, Gym, Game Area
Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly
Fridge, microwave, oven, stovetop

Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly

9.8 out of 10, Exceptional, (52)
"We had to gather a lot of family on short notice to say goodbye to a dying family member and this space was perfect for us all to gather and grieve together. There was plenty of sleeping space for everyone and it was conveniently lovlcated near parks and walking trails for our kiddos."
Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly
Modern Gem. Close to Mayo. Office and Fast Internet
Fridge, microwave, oven, stovetop

Modern Gem. Close to Mayo. Office and Fast Internet

9.6 out of 10, Exceptional, (4)
"This is a beautiful property, exactly as pictured. Extremely clean, beds were very comfortable, great location. "
Modern Gem. Close to Mayo. Office and Fast Internet
☆Oakley's Oasis, a Dharma Dwellings Designed Home☆
Fridge, microwave, oven, stovetop

☆Oakley's Oasis, a Dharma Dwellings Designed Home☆

10.0 out of 10, Exceptional, (26)
"Great place, would stay again!"
☆Oakley's Oasis, a Dharma Dwellings Designed Home☆
3 miles to Mayo, Four bed home, Covered By Faith
Fridge, microwave, oven, stovetop

3 miles to Mayo, Four bed home, Covered By Faith

2.0 star property
3 miles to Mayo, Four bed home, Covered By Faith
Lost Creek Executive Home on 200 acre horse Ranch w/Trout Stream
Fridge, microwave, oven, stovetop

Lost Creek Executive Home on 200 acre horse Ranch w/Trout Stream

9.8 out of 10, Exceptional, (6)
"This home was AMAZING and there was so much space. If it had more Beds, Futons or Couches available for LARGE GROUPS it could really bring in the bigger groups since the Mayo Civic Center is only 20 Minutes away. If you are looking for a great accommodating host and an amazing property...LOK NO FURTHER."
Lost Creek Executive Home on 200 acre horse Ranch w/Trout Stream
Silver Lake Oasis
Miscellaneous

Silver Lake Oasis

9.6 out of 10, Exceptional, (33)
"Cozy, mostly modern, except for the bathroom. Steep stairs to the bedroom. Love the location. Made a few casts from shore, but didn't catch any fish. Walk around to the lakefront a bit steep and unsteady. Otherwise, enjoyed our stay!"
Silver Lake Oasis
Charming Rochester Home - 2 Mi to Mayo Clinic!
TV, table football

Charming Rochester Home - 2 Mi to Mayo Clinic!

9.8 out of 10, Exceptional, (14)
"The house is perfect for a larger family. It had all the amenities of home and we enjoyed the game room in the basement. The property managers were responsive and very helpful. Would 100% stay again if in the area."
Charming Rochester Home - 2 Mi to Mayo Clinic!
Charming 2 Bed 1 Bath Home W/Fully Fenced in Back yard
Outdoor dining

Charming 2 Bed 1 Bath Home W/Fully Fenced in Back yard

9.4 out of 10, Exceptional, (11)
"Perfect size and proximity to Mayo Clinic and walking trails along the river. Would stay there agsin."
The price is AU$432
includes taxes & fees
30 Nov - 1 Dec
Charming 2 Bed 1 Bath Home W/Fully Fenced in Back yard
Next to Mayo Clinic 518A
Exterior

Next to Mayo Clinic 518A

9.6 out of 10, Exceptional, (18)
"This property was very clean and had everything we needed for our stay. It was located close to Mayo which made it convenient to walk to the clinic. I give this place a 10 rating would stay here again."
Next to Mayo Clinic 518A
Coastal Charm meets Farmhouse living in a cozy single-family. 8 min to Mayo.
Outdoor dining

Coastal Charm meets Farmhouse living in a cozy single-family. 8 min to Mayo.

10.0 out of 10, Exceptional, (4)
"A great place to stay. When we're using the place for sleeping arrangements, and bathroom uses."
Coastal Charm meets Farmhouse living in a cozy single-family. 8 min to Mayo.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Byron
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Other property types in Byron

The Berkman
Terrace/patio

The Berkman

3.0 star property
9.6 out of 10, Exceptional, (254)
"Clean & enjoyable stay. "
The price is AU$301
includes taxes & fees
13 Dec - 14 Dec
The Berkman
Broadway Plaza, Trademark Collection by Wyndham
Fridge, microwave, oven, stovetop

Broadway Plaza, Trademark Collection by Wyndham

3.0 star property
9.2 out of 10, Wonderful, (145)
"Great place to stay. Very handy for walking to the Mayo Clinic. Also very clean. Although we only stayed one night, it would be especially nice for longer stays as it really is a small apartment."
Broadway Plaza, Trademark Collection by Wyndham
Valley Cabin
Exterior

Valley Cabin

9.0 out of 10, Wonderful, (6)
"This is a great property. Peaceful, surrounded by fields & forests, birds singing, and fresh air. Wonderful parks and trails near by. Dan was a great host. I want to come back and stay in the fall and winter. This would also be a great place for a family get away"
The price is AU$209
includes taxes & fees
28 Nov - 29 Nov
Valley Cabin
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.
Unlock Black Friday deals