Otay Mesa Travel Guide
Tourist Guide
Popular places to visit
San Diego Zoo
One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and entertainment choices.
Mission Bay
Mission Bay is San Diego’s vast and beautiful outdoor playground with great weather and calm waters that seem made for watersports.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
A seaside village and a popular spot for holiday-makers for over a century, which today still retains its antique charm.
SeaWorld
A fun family favourite, where you can get up close to the local marine life, enjoy fun rides and be wowed by the performances.
Activities
From Tijuana: Valle de Guadalupe Shared Winery Tour
Crossing Borders: Tijuana Day Trip from San Diego
From Tijuana: Valle de Guadalupe Private Winery Tour
Our pick of the best Otay Mesa Hotel Deals
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Reviewed on 28 Jul. 2025
Handlery Hotel
Reviewed on 30 Jul. 2025
Wyndham San Diego Bayside
Reviewed on 31 Jul. 2025
Embassy Suites by Hilton San Diego Bay Downtown
Reviewed on 30 Jul. 2025
Manchester Grand Hyatt San Diego
Reviewed on 30 Jul. 2025
The Dana on Mission Bay
Reviewed on 30 Jul. 2025
Other neighbourhoods around Otay Mesa
Mid-City
While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Del Cerro
While there might not be top attractions in Del Cerro, you can explore the larger area and discover places like Cal Coast Credit Union Open Air Theater and Viejas Arena.
- Places of interest
- What kind of hotels are in Otay Mesa?
- Hotels Near San Diego, California
- More holiday ideas
- San Diego Zoo
- San Ysidro Border Crossing
- Petco Park
- Mission Beach
- Balboa Park
- Naval Base San Diego
- Port of San Diego
- USS Midway Museum
- Coronado Beach
- Naval Base Coronado
- Seaport Village
- B Street Cruise Ship Terminal
- Mission Beach Boardwalk
- Waterfront Park
- North Island Credit Union Amphitheatre
- Snapdragon Stadium
- Belmont Park
- San Diego Bay
What kind of hotels are in Otay Mesa?
Are there hotels near Otay Mesa?
Expedia's Latest Trends
- Union Square Hotels
- Brisbane hotels
- Hollywood Family Hotels
- East Los Angeles Hotels
- Fiji Marriott Resort Momi Bay
- Four Points By Sheraton Bali, Kuta
- Hollywood Hotels
- Family Hotels in Bali
- Joondalup Hotels
- Los Feliz Hotels
- Downtown Los Angeles Hotels
- Downtown San Francisco Hotels
- Mid City Hotels
- Oasia Hotel Novena, Singapore