Adults Only & Resorts in Southeast Missouri

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Adults Only

Best Southeast Missouri Adults Only

We don't have any properties that match your exact search

Recommended hotels in Southeast Missouri

Microtel Inn & Suites by Wyndham Sainte Genevieve
Relax in this stylish room with two single beds, a flat-screen TV, and a desk for work or relaxation.

Microtel Inn & Suites by Wyndham Sainte Genevieve

2.5 star property
8.8 out of 10, Excellent, (587)
"It was a great stay. Only thimg maybe more variety or hot breakfast."
The price is AU$152
includes taxes & fees
17 Aug - 18 Aug
Microtel Inn & Suites by Wyndham Sainte Genevieve
Postcard Cabins St. Francois
Situated in a wooded area, this cabin features a cozy outdoor space with a porch, bench, fire pit, and table.

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (24)
"Had a wonderful time"
The price is AU$205
includes taxes & fees
12 Aug - 13 Aug
Postcard Cabins St. Francois
Drury Inn & Suites Sikeston, MO
Relax in the serene courtyard, surrounded by lush greenery and comfortable seating.

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1005)
"Very clean, friendly staff, and reasonable rates. "
The price is AU$159
includes taxes & fees
17 Aug - 18 Aug
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Hayti Caruthersville
Relax in our spacious lobby with a seating area, fireplace, and stunning views.

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1002)
"We enjoyed our stay."
The price is AU$164
includes taxes & fees
16 Aug - 17 Aug
Drury Inn & Suites Hayti Caruthersville
Pear Tree Inn Sikeston
Relax in the spacious lobby with a mezzanine level, comfortable seating, and large windows.

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1005)
"Great place to stay with kids "
The price is AU$141
includes taxes & fees
16 Aug - 17 Aug
Pear Tree Inn Sikeston
Drury Inn & Suites Jackson MO
Relax in the hotel's spacious lobby, featuring a comfortable seating area with a sofa, coffee tables, and chairs.

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1006)
"We had a last minute reservation here. The staff was very pleasant, helpful and wonderful overall!!"
The price is AU$146
includes taxes & fees
17 Aug - 18 Aug
Drury Inn & Suites Jackson MO
Fairfield Inn & Suites by Marriott Poplar Bluff
Relax in the spacious lobby with a stone fireplace, comfortable seating, and a large window.

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (789)
"Excellent choice for a stopping point for group of friends traveling through poplar bluff."
The price is AU$171
includes taxes & fees
17 Aug - 18 Aug
Fairfield Inn & Suites by Marriott Poplar Bluff
The Riverview
Relax in a stylish room with two beds, a desk, and a city view.

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (378)
"A very cool destination!"
The price is AU$182
includes taxes & fees
17 Aug - 18 Aug
The Riverview
Holiday Inn Express & Suites Perryville by IHG
Welcome to our reception area, where guests can check in at the digital station and enjoy the vibrant artwork.

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
9.4 out of 10, Exceptional, (494)
"Super nice staff. Our room smelled so nice and clean. Breakfast was very good too! "
The price is AU$184
includes taxes & fees
14 Aug - 15 Aug
Holiday Inn Express & Suites Perryville by IHG
Shepherd Mountain Inn
Enjoy cooking in this well-equipped kitchen with a granite countertop, stainless steel appliances, and a sink.

Shepherd Mountain Inn

2.5 star property
9.2 out of 10, Wonderful, (288)
"Wonderful small town motel in a beautiful & quiet location."
Shepherd Mountain Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Southeast Missouri Hotel Reviews