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Top hotels and accommodation in Wickliffe

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
6.6 out of 10, (533)
"I just want to tell you I stay here a lot. I had never read the reviews before and it didn’t sound like a place I wanted to stay. But the rooms are big. On one side, you can come in from the outside or inside. It is close to halfway for me. Easy to get to. "
The price is AU$93
includes taxes & fees
1 Dec - 2 Dec
Super 8 by Wyndham Charleston/Sikeston East MO
Quality Inn Cairo I-57
2.5 star property
6.6 out of 10, (237)
"The room was very clean and the breakfast was pretty good. No complaints"
The price is AU$102
includes taxes & fees
6 Dec - 7 Dec
Quality Inn Cairo I-57
Quality Inn Charleston - Sikeston
2.5 star property
6.8 out of 10, (359)
"Great bed. "
The price is AU$98
includes taxes & fees
21 Dec - 22 Dec
Quality Inn Charleston - Sikeston
Eagle Inn Charleston
2.0 star property
6.8 out of 10, (95)
"Comfortable bed, easy access to room"
The price is AU$118
includes taxes & fees
23 Nov - 24 Nov
Eagle Inn Charleston
Charming 3-bedroom house near ball park in quiet neighborhood
10.0 out of 10, Exceptional, (3)
"The house is perfect, great location, very clean and well organized. The host has everything in order from Check-in to Check-out and everything in between. Great Place"
The price is AU$250
includes taxes & fees
23 Nov - 24 Nov
Charming 3-bedroom house near ball park in quiet neighborhood
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Beautiful view of the beach with palm trees

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Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.

Frequently asked questions

Where is the best place to stay in Wickliffe?

Located 24 mi (38.6 km) from the heart of Wickliffe, Comfort Suites is a top choice for your stay, based on our traveller data. Two other choices for your stay in the area are Comfort Inn Paducah I-24 and Auburn Place Hotel & Suites - Paducah. See all available top hotels, or vacation rentals in Wickliffe.

What are some of the best holiday rentals that Wickliffe has to offer?

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286: This holiday home rental outside of Wickliffe is located in a rural location, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a fridge, a stovetop and a microwave, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. See all vacation rentals in Wickliffe.

If I need to cancel my hotel reservation in Wickliffe, will I receive a refund?

Yes! The majority of hotel reservations are refundable if you cancel before the hotel’s cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Wickliffe.

What are some hotels with pools in Wickliffe?

Quality Inn Cairo I-57: Offers free full breakfast, a seasonal outdoor pool and free self-parking. View all hotels with pools in Wickliffe.

What is staying in Wickliffe like?

Travellers to Wickliffe will find plenty to explore and enjoy. There are 55 hotels and other accommodation options in the surrounding area. Find out more about Wickliffe.

What should I do while I'm visiting Wickliffe?

The picturesque setting of Mississippi River and Ohio River exemplify the area's natural beauty. You'll also find Ballard Wildlife Management Area and Columbus-Belmont State Park in the area. Take a look at what more there is to see and do in Expedia's Wickliffe guide.

What's the seasonal weather like in Wickliffe?

The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Wickliffe is 1537 mm.